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She first discussed how the restoration of glutathione would reduce stress on XMRV patients remarkably. Next, she covered the need to restore and or improve methylation. She suggested methofolate in B12, and specifically mentioned supplements called Deplin and Cerefolin NAC.
This practice started testing its neuroimmune patients and soon found they were treating XMRV positive patients with CFS, Fibromyalgia, Chronic Lyme Disease, Multiple Sclerosis, Parkinsons Disease, ALS, the list goes on.
If you test negative, they are not able to confirm it is absolutely negative. Until there is further understanding of the XMRV lifecycle, they can not confirm this.
. . . .
You “never see these in healthy people!” exclaimed Mikovits. She stressed how the positives and negatives are SO CLEAR.
Mikovits noted “especially the sickest, get negative antibody response, but positive culture.” I’ll cover treatment later, but she also noted that once some of these especially sick patients went on antiretrovirals they were able to create an antibody response. Prior to, their systems were just too weak. Creating an antibody response would cause the patient to then also report positive on serology.
I don't understand this either. Is Dr. Mikovits saying that patients cannot make antibodies to XMRV only? Or that a severely ill patient cannot make antibodies to lots of pathogens? The latter would suggest an AIDS-like presentation with the immune system completely unable to do its job. I know we have lots of co-infections, but that's different from an immune system unable to function by making antibodies. If Dr. Mikovits is saying patients can't make antibodies to XMRV alone, why would that be? Do they understand the mechanism for why the immune system would be unable to mount a response to one pathogen but not others?
I take it that populations of clonal T-cells are also found in people with autoimmune disorders - another intriguing autoimmune connection. I have to say one thing is REALLY frustrating. Dr. Peterson has been talking about these clonal T-cells at meetings for several years now. This is apparently an eye-opening finding - yet it has never shown up in the literature! Where is the paper that demonstrates to the world that a subset of people with CFS have this unusual and apparently rather dangerous (?) immune finding.
It is also disturbing to see references to oxidation, methylation cycle, NAC, B12, treating co-infections etc. as a major component of treatment. These ideas have been floating around for years and I don't see any change in CFS treatment or prognosis. We need evidence of a heavy-hitting drug that works. Maybe it will never be found, but that is what it will take--you can't supplement your way out of this disease even if it may help a little around the edges.
It is also disturbing to see references to oxidation, methylation cycle, NAC, B12, treating co-infections etc. as a major component of treatment. These ideas have been floating around for years and I don't see any change in CFS treatment or prognosis. We need evidence of a heavy-hitting drug that works. Maybe it will never be found, but that is what it will take--you can't supplement your way out of this disease even if it may help a little around the edges.
I would have had a different take years ago, but I've seen and experienced the results based on supplementation, glutathione and treating lyme and various viruses.
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Hi, pine108kell.
I'm sorry that you find this disturbing. I actually find it encouraging. It's clear that these things are not the total answer. I think we can agree on that. But there is a lot of evidence now that treating specifically to lift the partial methylation cycle block, which brings glutathione up automatically and lowers oxidative stress, is a significant benefit to many PWCs. Perhaps the reason, or part of the reason at least, is the effect this treatment has on the retroviruses.
Best regards,
Rich
Maybe Lannie or Cort can help me understand this. If WPI cannot confirm a sample is truly negative, then the Blood Working Group study is completely useless. But on the other hand, Dr. Mikovits seems to be completely confident in the negative results of testing of healthy people. This reads like a contradiction - either the positive/negative results are clear and reliable, or they are not. I don't understand how it can be both. Can anyone help me out?
Cort, I hadn't heard they show up in autoimmune diseases. Do you have a link? I know that in some cases they are an early marker for cancer. But the autoimmune connection would be interesting...
Rituximab is used in the treatment of many lymphomas, leukemias and transplant rejection. It has also been used off label for numerous autoimmune disorders such as Rheumatoid Arthritis, Multiple Sclerosis and Lupus to name just a few. The last note is very important, XMRV infected patients have clonal populations of gd T-cells. This is important, as look at the next slide
Maybe Lannie or Cort can help me understand this. If WPI cannot confirm a sample is truly negative, then the Blood Working Group study is completely useless. But on the other hand, Dr. Mikovits seems to be completely confident in the negative results of testing of healthy people. This reads like a contradiction - either the positive/negative results are clear and reliable, or they are not. I don't understand how it can be both. Can anyone help me out?
I don't understand this either. Is Dr. Mikovits saying that patients cannot make antibodies to XMRV only? Or that a severely ill patient cannot make antibodies to lots of pathogens? The latter would suggest an AIDS-like presentation with the immune system completely unable to do its job. I know we have lots of co-infections, but that's different from an immune system unable to function by making antibodies. If Dr. Mikovits is saying patients can't make antibodies to XMRV alone, why would that be? Do they understand the mechanism for why the immune system would be unable to mount a response to one pathogen but not others?