I am looking for information on the connection between Anal Fissures or Anal Cysts and CFS, but I have not had any luck. My sister-in-law, who has had CFS for over 15 years, ended up in the hospital in serious condition because of an anal fissure that became infected. The infection spread to her blood and became sepsis. Now my brother-in-law has a fluid filled fissure or cyst with a hard core. They are not sure what exactly it is. He is going to go into surgery to have it removed tomorrow before it gets bigger. Has anyone ever had this problem? If so, did your doctor tell you it is related to CFS or was it a secondary bacterial or parasite infection? As far as I know, they never did figure out the source of the fissure in my sister-in-law's case.