mitoMAN
Senior Member
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ARA-290 / Cibinetide
Already discussed briefly in 2015
https://forums.phoenixrising.me/threads/fast-track-approval-for-sfn-drug-ara290.36976/
ARA-290 is one of those compounds that has proven to produce similar results to IVIG for SFN Patients.
As I have read in a recent study that up to 70% of severe ME/CFS patients suffer from Small Fiber Neuropathy and autonomic dysfunction (most of them paired with POTS!) this could be a symptomatic treatment for a huge portion of our suffering.
Safety profile seems excellent so far.
It mainly works as an IRR (Innate Repair Receptor) Agonist and enables regrowth of small fibers and nerves. But it has also shown to act as a modulator of the innate immune system
This is extremly interesting for ME/CFS - directly targeting the innate immune system.
Cell Studies regarding Innate Immune Responses:
https://pubmed.ncbi.nlm.nih.gov/21410562/
https://www.nature.com/articles/s41598-017-13046-3
ARA-290 marketed as Cibinetide
Good summary about the study results on Youtube.:
Small Fiber Neuropathy and ARA-290 Results
Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Stud
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563705/
A quick overview I have posted on Reddit:
Already discussed briefly in 2015
https://forums.phoenixrising.me/threads/fast-track-approval-for-sfn-drug-ara290.36976/
ARA-290 is one of those compounds that has proven to produce similar results to IVIG for SFN Patients.
As I have read in a recent study that up to 70% of severe ME/CFS patients suffer from Small Fiber Neuropathy and autonomic dysfunction (most of them paired with POTS!) this could be a symptomatic treatment for a huge portion of our suffering.
Safety profile seems excellent so far.
It mainly works as an IRR (Innate Repair Receptor) Agonist and enables regrowth of small fibers and nerves. But it has also shown to act as a modulator of the innate immune system
This is extremly interesting for ME/CFS - directly targeting the innate immune system.
Cell Studies regarding Innate Immune Responses:
https://pubmed.ncbi.nlm.nih.gov/21410562/
The erythropoietin analogue ARA290 modulates the innate immune response and reduces Escherichia coli invasion into urothelial cells
https://www.nature.com/articles/s41598-017-13046-3
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
ARA-290 marketed as Cibinetide
Good summary about the study results on Youtube.:
Small Fiber Neuropathy and ARA-290 Results
Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Stud
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563705/
A quick overview I have posted on Reddit: