I've taken Kavinace in the past, but for the life of me can't remember if it was helpful or not. I was taking a whole bunch of things for sleep at the time.
If you're doing supplements, a cocktail hitting various neurotransmitters will likely be necessary.
If you learn self-muscle testing, you can test for tolerance without even opening the bottle. There are several videos on Youtube that show how to do it. This has become the most used tool in my toolkit.