• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Anyone on Progesterone?

tootsieroll

Senior Member
Messages
122
How can I implement progesterone if my cortisol is high. I’m afraid because progesterone converts to cortisol and I imagine that would not be a fun day. I need to use progesterone to stop bleeding. But with my severely high cortisol, i’m not sure how to do this.
 

Mary

Moderator Resource
Messages
17,293
Location
Southern California
@tootsieroll - you might try Seriphos to lower your cortisol. Seriphos is phosphorylated serine, NOT phosphatidyl serine, and I found if very effective when my night time cortisol levels were high, which caused severe insomnia which nothing would touch. I read it was best to take it in the morning due to circadian rhythm and found this to be true. I had to experiment to find the right dose, titrated up to 8 capsules a day initially (divided into 2 doses in the a.m.) - quite a high dose and I don't recommend anyone start with that. ItI was very effective and worked almost immediately. I eventually started to get extra tired and realized my cortisol levels were getting too low, so cut back and eventually was able to stop the Seriphos, but occasionally I need a low dose of it (1 or 2 (or 3) but not for awhile now.

I use progesterone cream and don't have any problem with it. Actually I think it helps with sleep.
 

tootsieroll

Senior Member
Messages
122
Thanks. I am trying Relora at the moment. Are you knowledgeable on hormones. I used Vitex and Calcium D glucarate to try and lower estrogen and prolactin. But I ended up with super dry skin/hair and beyond thirsty. From Vitex, first I experienced the Dopamine surge which was then followed by the adrenaline surge. I think dopamine may have caused cortisol/adrenaline to shoot up. I'm not sure whether my estrogen is too low. I know my progesterone ratio to estrogen is too low. Lowering prolactin will be tough since I don't break down dopamine well. So what cause the dryness? Am I now more estrogen dominant. Some say Vitex is estrogenic but it is used by people to raise progesterone. Confused.



Prolactin 24.8 5.0-27.0 ug/L
Reproductive and Gonadal

Estradiol 131 pmol/L
Estradiol adult female reference intervals------------------------------------------Follicular: 77-921 pmol/LMid-cycle: 139-2382 pmol/LLuteal: 77-1145 pmol/LPost-menopausal: <103 pmol/L

Progesterone <0.6 nmol/L
Progesterone adult female reference intervals---------------------------------------------Follicular: <1.7 nmol/LLuteal: 4.0-50.0 nmol/LPost-menopausal: <0.7 nmol/LEffective Oct 24, 2022 this test is performed ona new analyzer. Results are equivalent, andreference intervals are unchanged except forpost-menopausal stage.

Dehydroepiandrosterone [DHEA-S] 4.4 < 9.8 umol/L
Testosterone <0.4 < 1.8 nmol/L
Reference interval applies to AM collections.Total Testosterone levels may not reflect thebiologically-active testosterone when SHBG levelsare abnormal.

Thyroid Function
Thyroid Stimulating Hormone 1.16 0.32-4.00 mIU/L
Free T3 4.0 2.6-5.8 pmol/L
Thyroperoxidase Antibody HI 57 < 35 kIU/L
Anti-Thyroid peroxidase antibody values up to250 kIU/L may be seen in 5-10% of the normalpopulation without demonstrable thyroid disease.This incidence increases with age.
 

tootsieroll

Senior Member
Messages
122
Vitamin b6 can help some people lower prolactin.
Thanks! But doesn’t B6 also raise dopamine?

Also an update. Couldn’t tolerate Vitex due to it raising dopamine. It also felt very estrogenic. Relora helped for a day and then I woke up in a hot flash with heart palps. Found out it raises DHEA, which eventually raises estrogen. I think my only next step is to use actual progesterone. Unsure of how to dose it initially.

@Mary is Seriphos from a plant?
 

Rufous McKinney

Senior Member
Messages
13,202
I used bio-identifical progesterone cream it pretty successfully for about 15 years. (pre and post menopause)

I was pretty consistently HALF the standard dose (on a 20 days on 8 days off cycle)..
 

tootsieroll

Senior Member
Messages
122
I used bio-identifical progesterone cream it pretty successfully for about 15 years. (pre and post menopause)

I was pretty consistently HALF the standard dose (on a 20 days on 8 days off cycle)..
what is the standard dose. i've pretty estrogen dominant and profusely bleeding, so I was thinking 500mg cream daily for a few months to turn off the cycle and then come off slowly and work with my natural cycle. That is if I even have one. I'm sure I do since this didn't happen till a doctor gave me a detox supplement. Must have detoxed a lot of estrogen from liver and tissues and my progesterone is too low to handle it. I think 400mg and up is needed to oppose estrogen. what do you think?