Definitely a big yes for me for muscle wasting. I'm in my sixth year of ME/CFS and now severe, with the reducing activity the muscle wasting is really
showing in my legs and arms. I'm quite tall at 184cm and used to weigh near 90kg most of my life, now I'm 74kg and I expect to lose more as I struggle to eat enough. I remember losing 12kg in the first 6 weeks of getting ME.
I consider ME a cachectic disease, much like the systemic inflammatory state of cancer cachexia, and late stage HIV, malaria, severe burns and sepsis. I suspect this is due to the raised levels of TNF-alpha (aka cachectin). I've studied this condition quite a bit in order to understand how I can address it, unfortunately it is quite a refractory to treatment and quite problematic.
There is a natural muscle wasting inhibitor (TNF inhibitor) used by sports people but also used with some success in older people and in cancer cachexia, called HMB (Beta-Hydroxy-Beta MethylButrate)
. You can buy it readily as a supplement. I've just started trialing it recently, 2-3g per day in divided doses, and so far I've found it very positive improving cognition, appetite and functionality. I supplement this with full spectrum amino acids (essential plus non-essential) both in AA's (which I have to formulate) and Collagen form.
It's too early to call HMB a success for me yet, it's only been a week, but in a few more weeks I might report on it. I often say having ME is like being stuck in the ring with Mike Tyson, you might get yourself off the floor and sneak a few jabs with some new supplement, but he only gets pissed off and thumps you harder until you're back on the mat...I'm hoping HMB won't be like that.