Anyone else have a massive improvement from Tyrosine?

Learner1

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I’ve been on tyrosine 500 mg in the morning on empty stomach for a week and a half.
It seems to have taken the edge of the anxiety and depression that has been a part of my pem. For which I’m very grateful.

But it also seems to make me even more drowsy at daytime than usual.
Im considering to take it in the afternoon, but it’s magic seems to wear off a bit towards the evening, and I prefer the day to be anxi-less (that’s not a word?) over the evening and night…

So …any thoughts on how to keep the good effect and at the same time get rid of the side effect?
That's what tyrosine does.

I've taken as much as 6g a day, prescribed by my doctor. You might try going up to 2-3 g a day and see how you feel.
 

hapl808

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I think it's interesting the different reactions. I tried tyrosine for a few days and it made me even more exhausted and I think worsened my mood as well. Within 24 hours of stopping I felt much improved. Weird since I thought dopamine crashes seem to follow any exertion for me (part of my PEM reaction), but maybe it's something else. I do think it's hard to distinguish between adrenaline, dopamine, glutamate, etc. Many neurotransmitters seem to have overlapping functions.
 

Learner1

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I think it's interesting the different reactions. I tried tyrosine for a few days and it made me even more exhausted and I think worsened my mood as well. Within 24 hours of stopping I felt much improved. Weird since I thought dopamine crashes seem to follow any exertion for me (part of my PEM reaction), but maybe it's something else. I do think it's hard to distinguish between adrenaline, dopamine, glutamate, etc. Many neurotransmitters seem to have overlapping functions.
I found doing a plasma amino acid test as well as catecholamine testing to be tremendously helpful in sorting these things out rather than guessing. The microbiome also has a role in all this, too
 

hapl808

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Did you find the plasma amino acid test actionable? Did it show something like tyrosine out of range or just a bit low, and then supplementation improved symptoms? Seems like a useful test if it works like that. I've always been a bit skeptical of neurotransmitter urine tests, but haven't had the plasma amino acid test recommended to me.

I do believe that the microbiome is a large part of the picture, if not the actual root cause. My symptoms all seem to affect my gut. As I've mentioned even something like mental focus will give me gut problems the next day. I also wish there were a reliable microbiome testing company, but opinion also seems divided there.
 

Learner1

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Did you find the plasma amino acid test actionable? Did it show something like tyrosine out of range or just a bit low, and then supplementation improved symptoms? Seems like a useful test if it works like that. I've always been a bit skeptical of neurotransmitter urine tests, but haven't had the plasma amino acid test recommended to me.
Yes, I had:
  • Low methionine, explaining my far lower than expected homocysteine
  • Low glycine, which explained why just taking NAC wasn't raising my glutathione
  • High phenylalanine and low tyrosine which explained my chronically low dopamine and qualified me for Kuvan
  • Low lysine, making it harder to fight herpes viruses
  • Low isoleucine and leucine suggesting that taking BCAAs would help me, this avoiding PEM
  • Low ornithine and citrulline, leading to inability to clear ammonia and disrupted sleep.
My neurologist ram Neurolab which was useful.
I do believe that the microbiome is a large part of the picture, if not the actual root cause. My symptoms all seem to affect my gut. As I've mentioned even something like mental focus will give me gut problems the next day. I also wish there were a reliable microbiome testing company, but opinion also seems divided there.
GI Effects and GI Map are good for initial screening of h.pylori, candida, low SigA, calprotectin, gliadin antibodies, klebsiella, etc. Viome is good for actionable info on how to manipulate the microbiome.
 
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Yes, I had:
  • Low methionine, explaining my far lower than expected homocysteine
  • Low glycine, which explained why just taking NAC wasn't raising my glutathione
  • High phenylalanine and low tyrosine which explained my chronically low dopamine and qualified me for Kuvan
  • Low lysine, making it harder to fight herpes viruses
  • Low isoleucine and leucine suggesting that taking BCAAs would help me, this avoiding PEM
  • Low ornithine and citrulline, leading to inability to clear ammonia and disrupted sleep.
My neurologist ram Neurolab which was useful.
GI Effects and GI Map are good for initial screening of h.pylori, candida, low SigA, calprotectin, gliadin antibodies, klebsiella, etc. Viome is good for actionable info on how to manipulate the microbiome.
So to fix the ones that were low, did you just supplement them directly, and did it noticeably help?
 

Learner1

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I’ve been on tyrosine 500 mg in the morning on empty stomach for a week and a half.
It seems to have taken the edge of the anxiety and depression that has been a part of my pem. For which I’m very grateful.

But it also seems to make me even more drowsy at daytime than usual.
Im considering to take it in the afternoon, but it’s magic seems to wear off a bit towards the evening, and I prefer the day to be anxi-less (that’s not a word?) over the evening and night…

So …any thoughts on how to keep the good effect and at the same time get rid of the side effect?
I’ve ended up taking 500 mg when the PEM hits hard, and not on regular basis.
So those days I’ll be half dead anyway - and the anxiety grows big and bad -
I’ll take a 500 mg pill.
 

Learner1

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I’ve ended up taking 500 mg when the PEM hits hard, and not on regular basis.
So those days I’ll be half dead anyway - and the anxiety grows big and bad -
I’ll take a 500 mg pill.
500mg is a relatively small amount. When I first had issues with lethargy data lack of dopamine and low tyrosine, my doctor suggested taking 6 g of tyrosine. I did that for a couple of months, then reduced it to 3 g and then to 2g, then to 1g. I think you could go much higher as long as you don't experience irritability, fast pulse, or high blood pressure, which would be symptoms of overdoing it.
 

Pearshaped

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It seems to cut through brain fog and fatigue like a knife through butter. I have to wonder if it's possible to be tyrosine deficient if you have malabsorption issues?

Could it be modulating the immune system somehow?
Do you have tyroid issues ? have you been tested for hypotyroid and for autoimmune stuff re thyroid ?
Because tyrosine is often very helpful in ppl with these issues.