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Anyone else have a massive improvement from Tyrosine?

drob31

Senior Member
Messages
1,487
It seems to cut through brain fog and fatigue like a knife through butter. I have to wonder if it's possible to be tyrosine deficient if you have malabsorption issues?

Could it be modulating the immune system somehow?
 

drob31

Senior Member
Messages
1,487
These are the 2 Huge factors in my sons health. Would be great if this could help

You mean diet and thyroid?

I've learned a bit about tyrosine, by experimenting, and more is not always better, also it may or may not need to be pulsed.
 

Mij

Messages
2,353
Tyrosine and Phenylalanine were the lowest on my amino acid panel, but when I supplemented with Tyrosine I felt a bit hyper.

Phenylalanine converts to Tyrosine. Perhaps I should have taken Phenylalanine instead to see how that works out.
 

ljimbo423

Senior Member
Messages
4,705
Location
United States, New Hampshire
I've learned a bit about tyrosine, by experimenting, and more is not always better, also it may or may not need to be pulsed.

I have been taking tyrosine for several years, daily. I started taking L-tyrosine and it helped noticeably. Then I tried N-acety-tyrosine and it gave me a much stronger effect, at a much lower dose.

The type that works best for someone seems to be very individual though. If I take too much, I get too hyper and have trouble sleeping. The boost it gives in dopamine seems to be why it helps me so much.

I also think it would probably work better pulsed but it is so important to my clarity of mind, I don't want to stop it even for a day. If I did I'd probably feel like I was sleep walking all the time.;)

Jim
 

Isaiah 58:11

Senior Member
Messages
116
Location
A Sun-Scorched Land
I was tyrosine deficient on a test. I tried a bottle and didn't seem to notice anything but I was doing a lot of different things at that point. I just ordered a higher quality tyrosine last week but I can't remember how much I had been told to take. What dosage has been working for you all?

@Tammy interesting on the phenylalanine. I drink coffee like mad but it never makes me feel like diet coke used to! If only diet sodas didn't contribute to insulin resistance... Maybe I need a side of phenylalanine with my coffee? Do you suppose it was the phenylalanine itself or the downstream tyrosine that helped. How much did you take?
 

Alvin2

The good news is patients don't die the bad news..
Messages
2,950
Had no effect on me, though it was years ago i tried it
 

Tammy

Senior Member
Messages
2,167
Location
New Mexico
@Tammy interesting on the phenylalanine. I drink coffee like mad but it never makes me feel like diet coke used to! If only diet sodas didn't contribute to insulin resistance... Maybe I need a side of phenylalanine with my coffee? Do you suppose it was the phenylalanine itself or the downstream tyrosine that helped. How much did you take?

My guess is it was the downstream tyrosine that helped. Sorry I don't remember how much I took but my body was pretty sensitive so if I had to take a guess..........I probably took a conservative dose.
 

Chocolove

Tournament of the Phoenix - Rise Again
Messages
548
@drob31 I too got a fairly immediate hit from Tyrosine. If you try amino acids on your tongue you will usually respond within 10 minutes if it will affect you. It amped me up pretty good. However that pushed my poor functioning adrenals into a crash. I hope you are not headed for a crash and further damage. If you are feeling tired it would be wise to avoid this stimulant which could push you too far. Tread with caution.

Phenylalanine and tyrosine are precursors to the body's three "fight or flight" hormones, dopamine, epinephrine (adrenaline) and norepinephrine.
Phenylalanine---converts to--->Tyrosine---converts to--->DOPA---converts to--->Dopamine
Independent Supportive Research:
University of Nebraska at Lincoln
Indiana State University
Rensselaer Polytechnic Institute

Unfortunately it is not always the fix to supply what is missing to feel good. One can overload a system that the body has down-regulated because it cannot handle the load...something else may be in need of repair.

Julia Ross published a book on using amino acids for mood as certain amino acids are precursors to certain neurotransmitters and thus affect neurotransmitter deficiency. She posted a questionnaire which can help you figure out which amino acids might affect you. It certainly gives you a clue as too how your system is operating. See: http://moodcure.com/take_the_mood_type_questionnaire.html
This article may also be of interest: https://nootriment.com/l-tyrosine-for-anxiety/

"Tyrosine is a precursor to neurotransmitters and hormones
In dopaminergic cells in the brain, tyrosine is converted to L-DOPA by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into other catecholamines, such as norepinephrine (noradrenaline) and epinephrine (adrenaline).
The thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the colloid of the thyroid also are derived from tyrosine.
Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),[15] but has little if any effect on mood in normal subjects.[16][17][18]" https://en.wikipedia.org/wiki/Tyrosine

"It's rare to be deficient in tyrosine. Low levels have been associated with low blood pressure, low body temperature, and an underactive thyroid. This does not mean, however, that taking tyrosine supplements will help any of these conditions."
http://www.umm.edu/health/medical/altmed/supplement/tyrosine

[PDF]Neurotransmitter Deficiency and Cortisol Excess - The Mood Cure
https://www.moodcure.com/pdfs/Townsend-Letter-NNTI article.docx.pdf
... in response to a T.L. article, “The Cortisol-Sleep ... and well to neurotransmitter precursors such as GABA, tryptophan, and/or melatonin. Others .... exacerbated by the use of the stimulating amino acid, l-tyrosine.

For example, insomnia caused by high cortisol is not eliminated, but, rather, exacerbated by the use of the stimulating amino acid, l-tyrosine (l-tyrosine converts to noradrenaline and adrenaline.) The Hudson/Bush article recommends tyrosine, but also mentions that elevated noradrenaline is part of sleep disturbances along with excessive cortisol...? If indicated by the noradrenalin deficiency symptoms of fatigue or poor concentration, we might recommend tyrosine in the AM only. Typically we forgo such treatment until after cortisol levels are lowered, and often find that the resulting improved sleep alone restores energy and focus...

Repletion and balancing of amino acids:
Amino acid repletion is usually taken in conjunction with a variety of other vitamins and minerals and brain boosting supplements because they work together and need one another to support good brain function. For example, pyridoxal-5-phosphate is needed for the conversion of tryptophan to serotonin.

Repletion therapy must be carried out carefully and no one should take matters into their own hands without the proper guidance. Most failures occur under inexperienced hands. For example, if you take 5-HTP and no other supplement(s), or if you take improperly balanced 5-HTP, you can easily deplete the dopamine in your system. If you take L-DOPA alone, or improperly balanced L-DOPA, you can easily deplete the serotonin in your system, as well as the L-tryptophan, sulfur-based amino acids, and tyrosine. One must always be aware of the balances of brain boosting supplements and always seek advice from one’s primary medical physician....
Insomnia that is caused by high levels of cortisol is not solved, but instead exacerbated by taking l-tyrosine, a stimulating amino acid that converts into noradrenaline and adrenaline.
https://www.drlam.com/blog/brain-boosting-supplements-and-afs-part-5/11234/
https://www.drlam.com/blog/biological-rhythm-disruptions-and-adrenal-fatigue-syndrome-part-2/11319/

...achieving proper neurotransmitter balance can be very difficult to do. This is because there are several steps during the conversion of amino acids into their respective neurotransmitters and in the degradation (or breakdown) of neurotransmitters where there is a competition of sorts for precious resources.

Figure 1 shows how tyrosine is converted into dopamine, norepinephrine and epinephrine and how tryptophan is converted to serotonin.

The important thing to see is that the enzyme needed for these conversions is the same (i.e., aromatic amino acid decarboxylase). This means that tyrosine competes with tryptophan (or 5-HTP) to be converted into dopamine or serotonin, respectively.

This may not seem like that big of a deal in theory, but in practice it often makes the difference between not seeing any results or the complete resolution of symptoms.

In addition, there are many interactions noted in the literature between amino-acids and neurotransmitters:



Illustration taken from Marty Hinz, MD.

...If you take only one amino acid precursor, the administered amino acid will dominate the enzyme and compromise proper production of the other system’s neurotransmitters, creating further imbalance, which can lead to more and greater symptoms.
http://amino-acid-therapy.com/neurotransmitters/proper-neurotransmitter-balance/

...In the first step, tyrosine hydroxylase converts L-tyrosine to L-dopa, once again using tetrahydrobiopterin as a cofactor. L-dopa is then converted to dopamine by AADC, using pyridoxal-5-phosphate as a cofactor.

A May 2009 review in “Molecular Genetics and Metabolism” reported that a genetic disorder called AADC deficiency, in which amino acid decarboxylase is only partially functional, can be ameliorated by treatment with pyridoxal-5-phosphate.

Minerals
Both tyrosine hydroxylase and tryptophan hydroxylase contain iron. As this integral metallic element alternates between two electronic states, it helps to regulate the activity of the hydroxylase enzymes, according to a February 2006 review in “Biochemistry.” Magnesium and zinc help to potentiate the activities of serotonin and dopamine but are not intimately involved in neurotransmitter synthesis.

Recommendations
Adequate protein intake usually ensures a sufficient supply of amino acid precursors for neurotransmitter synthesis.
http://www.livestrong.com/article/431600-what-minerals-convert-amino-acids-to-dopamine-serotonin/

L-Tyrosine Deficiency Symptoms + Warning Signs of Low Dopamine
https://nootriment.com/l-tyrosine-deficiency/
 

drob31

Senior Member
Messages
1,487
@drob31 I too got a fairly immediate hit from Tyrosine. If you try amino acids on your tongue you will usually respond within 10 minutes if it will affect you. It amped me up pretty good. However that pushed my poor functioning adrenals into a crash. I hope you are not headed for a crash and further damage. If you are feeling tired it would be wise to avoid this stimulant which could push you too far. Tread with caution.

Phenylalanine and tyrosine are precursors to the body's three "fight or flight" hormones, dopamine, epinephrine (adrenaline) and norepinephrine.
Phenylalanine---converts to--->Tyrosine---converts to--->DOPA---converts to--->Dopamine
Independent Supportive Research:
University of Nebraska at Lincoln
Indiana State University
Rensselaer Polytechnic Institute

Unfortunately it is not always the fix to supply what is missing to feel good. One can overload a system that the body has down-regulated because it cannot handle the load...something else may be in need of repair.

Julia Ross published a book on using amino acids for mood as certain amino acids are precursors to certain neurotransmitters and thus affect neurotransmitter deficiency. She posted a questionnaire which can help you figure out which amino acids might affect you. It certainly gives you a clue as too how your system is operating. See: http://moodcure.com/take_the_mood_type_questionnaire.html
This article may also be of interest: https://nootriment.com/l-tyrosine-for-anxiety/

"Tyrosine is a precursor to neurotransmitters and hormones
In dopaminergic cells in the brain, tyrosine is converted to L-DOPA by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into other catecholamines, such as norepinephrine (noradrenaline) and epinephrine (adrenaline).
The thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the colloid of the thyroid also are derived from tyrosine.
Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),[15] but has little if any effect on mood in normal subjects.[16][17][18]" https://en.wikipedia.org/wiki/Tyrosine

"It's rare to be deficient in tyrosine. Low levels have been associated with low blood pressure, low body temperature, and an underactive thyroid. This does not mean, however, that taking tyrosine supplements will help any of these conditions."
http://www.umm.edu/health/medical/altmed/supplement/tyrosine

[PDF]Neurotransmitter Deficiency and Cortisol Excess - The Mood Cure
https://www.moodcure.com/pdfs/Townsend-Letter-NNTI article.docx.pdf

... in response to a T.L. article, “The Cortisol-Sleep ... and well to neurotransmitter precursors such as GABA, tryptophan, and/or melatonin. Others .... exacerbated by the use of the stimulating amino acid, l-tyrosine.



Repletion and balancing of amino acids:

https://www.drlam.com/blog/brain-boosting-supplements-and-afs-part-5/11234/
https://www.drlam.com/blog/biological-rhythm-disruptions-and-adrenal-fatigue-syndrome-part-2/11319/


http://amino-acid-therapy.com/neurotransmitters/proper-neurotransmitter-balance/


http://www.livestrong.com/article/431600-what-minerals-convert-amino-acids-to-dopamine-serotonin/

L-Tyrosine Deficiency Symptoms + Warning Signs of Low Dopamine
https://nootriment.com/l-tyrosine-deficiency/


Thanks for the detailed write-up. I did use Tyrosine 500 mg in the morning on an empty stomach for a good 2 month period, and it helped dramatically. I did seem to crash myself for about 2 weeks but I think it was because I was using allot of caffeine next to it. I cut out the caffeine and I'm back on tyrosine again at a lower dose. (250 mg), and I may pulse it.

I also had dramatic improvements a few years ago when I had tyrosine + iodine, but I attribute it to the tyrosine, I think the iodine made me go hypo.

In any case, there seems to be missing co-factors or signaling issues, but it's clear that dopamine is part of the puzzle.
 

andyguitar

Moderator
Messages
6,581
Location
South east England
Well those who are interested in this thread have certainly come up with some usefull info. Well done! I spent several years working for someone with severe ME. On the amino acid front the most effective were the Branched Chain Amino Acids. Used by sports people, among other things they stimulate the release of glycogen from the liver. You need that to fuel your brain. They have other effects which might help ME. If you want to give them a try just follow the instuctions on the pack. But best not to take them within 4 hours of going to bed for the ni
 

drob31

Senior Member
Messages
1,487
This actually all ties in with the central fatigue hypothesis, where seratonin levels are too high in the brain while dopamine levels are too low. This is what they noticed in atheletes who exhibited CFS like symptoms.