Last year, twice, I took antibiotics probably about 9 months apart(I had been many years previous with not taking any, and really not one to get sick(other than this chronic ME/CFS)). The first time, I had been having months of morning redness over one cheek that would last a few hours after getting up, and it was always warm to the touch. I never had fever with it, and it would go away by mid-morning. One morning my eyeball on that side kind of hurt to move. I don't usually have an illnesses, and not really a sinus person, but I thought maybe it was sinus going on without fever, and finally went to an urgent care. He didn't think it was an infection, but agreed to let me do antibiotics because it had been going on for so long. Within two days of starting the antibiotics, I felt pretty good! That constant malaise totally went away! At some point, the malaise came back. Fast forward to what appeared as a bladder infection. I say that, because I used telemedicine for that so no way of testing. I was prescribed an antibiotic, and sure enough, the malaise went away again. I never had a fever that would signal an infection. The malaise eventually comes back. What in the heck is going on in my body that an antibiotic makes me feel so much better?