Anti-inflammatory brain cells activated by signals from gut bacteria


Senior Member

"It turns out bacteria in the gut modulate the expression of a signaling molecule called interferon-gamma. When this molecule reaches the brain it then induces these specific astrocytes to help kill the pro-inflammatory immune cells."

“Finding microbiome-controlled anti-inflammatory subsets of astrocytes is an important advance in our understanding of CNS inflammation and its regulation,”


Senior Member
United States, New Hampshire
Excellent find @Wishful I expect @ljimbo423 will find it interesting.

I read it. It's interesting to hear about "anti-inflammatory" actions in the brain from bacteria in the gut. Most studies refer to bacteria in the gut causing inflammation.

This quote is from the article-

The research, led by scientists from Brigham and Women’s Hospital, focused on astrocytes, a common type of non-neuronal cell abundant in the brain and spinal cord. Astrocytes play a number of diverse roles in the brain from helping regulate neural activity to maintaining the blood-brain barrier.

I think a "leaky" blood brain barrier (BBB) might play a role in ME/CFS. I have HUGE sensitivities to almost every medication, vitamin or herb on the planet. My best guess is that's being caused by a compromised or "leaky" BBB.

I can't think of any other reason that something a simple as 200 mg of ginger root powder, etc, would cause extreme anxiety and a tremendous increase in energy.
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