ALCAR, Ashwagandha, Bacopa, Alpha-Lipoic Acid all make me tired. Acetylcholine problem?

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ALCAR, Ashwagandha, Bacopa, Alpha-Lipoic Acid all that supplements make me tired after a day of usage. What is common in these supplements is they all alter acetylcholine in some way. I was wondering if this is the reason why I am tired if I take it and if I could do anything about it and take these supplements.

DMEA doesn't give me any tiredness. So I have been thinking. Is the problem that all that supps depletes choline (by -increased acetylcholine for memory/focus).

Any thoughts?
 
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@newbie1985
I'd be interested in all those questions, too.

I reacted poorly to ashwagandha, which I'd had high hopes for. Still have an unopened bottle of Bacopa that I'm afraid to try, so more thoughts on that would be welcome as well. ALA created problems as well, but now I can't recall what they were, just that I had to stop it and have a shite load of it on hand, which I'd love not to waste, ditto Acetyl-L-Carnitine, which has so many side benefits that it's a shame to watch it loitering on my kitchen counter, back in the corner, looking all sullen and forlorn. I'd put in the same cabinet as the Bacopa, but I'm afraid they'd get together and start plotting something unpleasant.
 
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It's difficult to say, but carnitine has the hability to prevent T3 and T4 action
Well, that would definitely explain that. Still not sure why an adaptogen like ashwagandha would react badly in my system, and still hesitant to give Bacopa a try before my bottle ages past the 'use by' date.

Thanks, as always, @pattismith , you're terrific :hug:
 
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Another reason could be the action on GABA receptors of Ashwagandha and Bacopa.
@JES
That was my assumption with the ashwagandha, and the reason I didn't start the Bacopa Monnieri. I seem to have unpleasantly down-regulated GABA receptors along with profound sensitivity to anything excitotoxic, along with all the usual suspects like PEMs and POTs. None of which explains the ALCAR, tho strong antioxidant activity would seem to. Thanks for the reminder. There's so much I've forgotten or just can't hang on to apparently. Very depressing.

But I refuse to cave. Somewhere there's something that will continue to improve this, with or without setbacks. There already has been. But I've hit a plateau, and a bit of a backslide. And although I stopped looking for a cure a while back, some slow, steady continued improvement would be, like, great.