Hi RLC
not self treating but unde a doc who treats alot of patients with these hormones. As for stopping hydrocort, i havent used it yet and tests for cortisol have come back fine, ats blood and saliva testing. Im not sure we are on the same page with testosterone and cortisol, the info i was rehashing was from another board on male hormone restoration, i think we are getting regulate mixed up with stimulate as thats wha Lh and FSH do, but i think they were refering to increasing cortisol levels lower T levels and this is better then E2 doing it, from my understanding its either cortisol or E2 to choose from and for male health cortisol is apparently the one to go for. Heres a copy of a reply i had back from supposed hormone expert,
Originally Posted by heapsreal
hi, please correct me if Im wrong, aside from possible absorptions factors with creams/TD, do compounded creams/TD have reduced aromitisation to E2 then injections and more convertion to DHT then injections or is it the other way around?
It's neither.
The degree of aromatization of transdermal testosterone is a function of :
a) how fast you absorb transdermal T
......this is dependant on T dose and the base,
......the faster you absorb T, the more likely it is to cause aromatization if your cortisol can't ramp up enough to downregulate the increase in T metabolism
b) your body fat content
......your body fat is an estrogen generation factory)
c) the ability of your body to ramp up cortisol to downregulate your T
......we are much much better off when our body can downregulate our T metabolism using cortisol, otherwise it will aromatise T into E2 and downregulate T using E2.
The degree of aromatization of IM injected T cypionate testosterone is a function of :
a) how fast your IM injected T cypionate converts into T
......this is dependant on T dose,
......the faster you absorb T, the more likely it is to cause aromatization if your cortisol can't ramp up enough to downregulate the increase in T metabolism
b) your body fat content
......your body fat is an estrogen generation factory)
c) the ability of your body to ramp up cortisol to downregulate your T
......we are much much better off when our body can downregulate our T metabolism using cortisol, otherwise it will aromatise T into E2 and downregulate T using E2.
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That the only differentiator in the two scenarios is:
a) how fast you absorb transdermal T
......this is dependant on T dose, and the carrier used,
versus:
a) how fast your IM injected T cypionate converts into T
......this is dependant on T dose.
The comparison of these two situations is way too complex to be achieved theoretically, so you and your medical professional adviser will need to do some therapeutic trials (dosage response trials) to determine the outcomes.
Quote:
Originally Posted by heapsreal
Also with creams etc if absorbed well, are testosterone levels more stable then injections.
Testosterone metabolism is far more important than testosterone levels.
Testosterone metabolism is regulated by your cortisol preferably, and in the absence of adequate cortisol, your testosterone metabolism will be regulated by E2.
In other words, your mission is to balance your rate of cortisol production with your testosterone dosage, to achieve stability, not to stabilize your serum T level and let your cortisol fluctuate because of a lack of awareness that you should be managing your cortisol.
Quote:
Originally Posted by heapsreal
I do know most guys prefer injection but just wondering if its absorption reason.
I disagree with this statement. There are more males using transdermal T for the purposes of achieving physiologic levels of T than there are males using injected T for the purposes of achieving physiologic levels of T.
The numbers speak for themselves.
100% of bodybuilders use injected T (or injected anabolic steriods) to achieve supra physiologic levels of T, but their preference is 100% not applicable to the goal of achieving physiologic levels of T..
Quote:
Originally Posted by heapsreal
One last question, does anyone buy their arimidex from 4RX online pharmacy as its almost 3 times cheaper then local pharmacy's. I have brought other meds from the guys with no hassles.
If you need any arimidex at all, then you're still far from optimized in your hormone modulation therapy regime. You should do your best to balance your T dosage with your body's ability to produce cortisol, so that you don't need arimidex.
Just because other forums may preach the use of arimidex to suppress T, doesn't mean they understand T metabolism - they don't. They understand T levels, but they don't understand the critical interactions between T metabolism, cortisol metabolism and E2 metabolism - and these interactions are far more important than serum levels.
This is explained in the following post:
testosterone boost 101, part 2:
http://musclechatroom.com/forum/show...5&postcount=12
.
__________________
Warning:
A) Some males excrete hormones very slowly. Normal doses of hormones, in these males, accumulate and create symptoms of excess. These males must monitor hormone levels very carefully to ensure their serum levels don't keep rising and rising.
B) Some males excrete hormones very quickly. These people require relatively high and frequent doses of hormones, and the cost of hormone supplementation, for these people, is relatively high.
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Last edited by chilln; 6 Days Ago at 09:37 PM.
Please argue these points if u have any further info to add.
cheers!!!
Hi heapsreal do you have your cortisol results? my concern with you saying that they where low along with DHEA-S is that it indicates Adrenal Insufficiency not Adrenal Fatigue, AI is alot more serious and treating with Pregnenolone cream will not fix it. The fact that you feel worse after stopping Hydrocortisone also makes either primary or secondary adrenal insufficiency quite likly.
Testosterone isn't regulated by cortisol, it is regulated by Gonadotropin releasing hormone (GnRH) which is made in the hypothalamus which sends a message to the Pituitary gland which then releases Folic stimulating hormone (FSH) and Luteinizing hormone (LH) which triggers the testes to make testosterone, LH and FSH should be measured by blood test to see if there is a problem in pituitary.
Pituitary problems can also cause HYpothyroidism it's called Secondary Hypothroidism TSH is normaly low with this but sometimes they can be high which you have info about it here
http://healthguide.howstuffworks.com/hypothyroidism-secondary-dictionary.htm
My feeling is that it is very important to get the right tests done before trying to self medicate these are serious conditions which if you have, need to be treated correctly and if treated correctly people can get their lives back very quickly, your endo should have done all this for you because your tests indicate there is the possibilty of you having these condition.
All the best
