It looks like we've tried many of the same things! I used to take 400 mg magnesium glycinate before bed and 300 mg more middle of the night. Now I spread it more throughout the day, 100 mg with breakfast and lunch, 200 mg with dinner, 200 mg before bed and 200 mg middle of the night.
For niacin, I take 400 mg before bed and 300 mg middle of the night. I found the kind that makes you flush works the best. I tried it once in the morning but it made me tired - I think probably slowed down methylation, but it helps me sleep at night.
Afraid not - Sorry! It's crazy that so many of us have paradoxical reactions to various things. And I'm really not an expert on Freddd's protocol or methylation. All I know is that folate has helped my energy quite a bit, but it also caused potassium deficiency, and I've had to supplement with potassium for over 10 years now, but that's fine - it works and I'm able to keep taking folate.
About Seriphos - it worked best for me taking it in the morning. But I don't think my cortisol pattern is flipped so I think trying it at night is worth a try, as @Learner1
suggested. When I took it at night, it gave me horrible insomnia.
I am having a conundrum I'm trying to sort out right now - it's my paradoxical reaction to l-citrulline and possibly beet juice. This is tangentially related to sleep so hopefully not too off-topic. I tried l-citrulline for energy and to lower BP, . It worked really well for energy, but then raised my BP alarmingly high (in the 180's). I tried it again the other day after not taking it for a year - it gave me a little energy, but my BP spiked again. It's supposed to be a vasodilator and lower BP, not raise it.
Anyways, I drank some beet juice the other night (to lower my BP from the l-citrulline) and it helped, and also, I slept pretty well that night. I didn't make the connection until last night I was wrestling again wtih middle of the night insomnia and remembered the beet juice from the other night. So I opened a can of beets and drank the juice and was back to sleep within 15 - 30 minutes, and slept the rest of the night - only my BP was higher this morning instead of lower! arrggghhh!!! I have to experiment some more - but the beet juice really did seem to help my sleep a lot. So you might give it a try. There are a lot of powdered beet supplements but they didn't do much for me. I want to experiment some more with this - I believe it all has to do with NO, and now am looking into Martin Pall's protocol, thanks to @Learner1
Anyways, you might look into NO (nitric oxide) and sleep. btw, beet juice has lowered my BP before so I hope last night was just an anomaly, but have to experiment some more.
ETA: Beets are high in oxalates, which doesn't seem to be a problem for me though it is for many people.