Abilify and Prozac (CYP2D6 inhibitor)


Senior Member

Abilify's prospectus says:

Quinidine and other CYP2D6 inhibitors

In a clinical trial in healthy subjects, a strong inhibitor of CYP2D6 (quinidine) increased the AUC of aripiprazole by 107%, while Cmax was unchanged. The AUC and Cmax of dehydro-aripiprazole, the active metabolite, decreased by 32% and 47%, respectively. The dose of aripiprazole should be reduced to half the prescribed dose if aripiprazole is co-administered with quinidine. Other strong CYP2D6 inhibitors, such as fluoxetine or paroxetine, may have similar effects and therefore similar dose reductions should be given.

Has anyone combined Abilify with Prozac? I understand that I should lower the dose of Abilify a little. But how far? I was taking 0.5mg of Abilify and now I start Fluoxetine 20mg.