pattismith
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An anecdotal report by an Oxford basic neuroscientist: effects of acetyl-dl-leucine on cognitive function and mobility in the elderly
First Online: 28 April 2016
Dear Sirs,
F.P.’s father is a 90-year-old retired physician with no signs of dementia. He has experienced progressive postural imbalance for 5 years with no extrapyramidal or cerebellar signs. He has encountered incomplete arousal wakefulness over the past 2 years, but has normal sleep patterns. He had polio in his 20s and has aspects of post-polio syndrome, including partial vocal cord paralysis, muscle weakness and spinal misalignment. He leads an independent active life, reads prolifically and uses a laptop computer to communicate with his family. His only medication was glaucoma eye drops at the time of this study.
Treatment with acetyl-dl-leucine (Tanganil™) was started because the patient was suffering from imbalance and gait disorder, two symptoms reported responsive to Tanganil [1, 2]. He initiated a 1-month course comprising nine 500 mg capsules taken TID with meals, i.e., a total daily dosage of 4.5 g. By 7–10 days of treatment he was more confident walking due to improved...
- Frances Platt (1)
- Michael Strupp (2)
- Department of Pharmacology, University of Oxford, Oxford UK
- Department of Neurology and German Center for Vertigo and Balance Disorders, University Hospital Munich, Munich Germany
First Online: 28 April 2016
Dear Sirs,
F.P.’s father is a 90-year-old retired physician with no signs of dementia. He has experienced progressive postural imbalance for 5 years with no extrapyramidal or cerebellar signs. He has encountered incomplete arousal wakefulness over the past 2 years, but has normal sleep patterns. He had polio in his 20s and has aspects of post-polio syndrome, including partial vocal cord paralysis, muscle weakness and spinal misalignment. He leads an independent active life, reads prolifically and uses a laptop computer to communicate with his family. His only medication was glaucoma eye drops at the time of this study.
Treatment with acetyl-dl-leucine (Tanganil™) was started because the patient was suffering from imbalance and gait disorder, two symptoms reported responsive to Tanganil [1, 2]. He initiated a 1-month course comprising nine 500 mg capsules taken TID with meals, i.e., a total daily dosage of 4.5 g. By 7–10 days of treatment he was more confident walking due to improved...
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