• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

A multi-omics based anti-inflammatory immune signature characterizes Long COVID Syndrome (Kovarik et al, 2022)

Messages
600
Abstract

To investigate Long COVID Syndrome (LCS) pathophysiology, we performed an exploratory study with blood plasma derived from three groups: 1) healthy vaccinated individuals without SARS-CoV-2 exposure; 2) asymptomatic recovered patients at least three months after SARS-CoV-2 infection and; 3) symptomatic patients at least 3 months after SARS-CoV-2 infection with chronic fatigue syndrome or similar symptoms, here designated as Long COVID Syndrome (LCS) patients. Multiplex cytokine profiling indicated slightly elevated pro-inflammatory cytokine levels in recovered individuals in contrast to LCS patients. Plasma proteomics demonstrated low levels of acute phase proteins and macrophage-derived secreted proteins in LCS. High levels of anti-inflammatory oxylipins including omega-3 fatty acids in LCS were detected by eicosadomics, whereas targeted metabolic profiling indicated high levels of anti-inflammatory osmolytes taurine and hypaphorine, but low amino acid and triglyceride levels and deregulated acylcarnithines. A model considering alternatively polarized macrophages as a major contributor for these molecular alterations is presented.


Preprint:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719844/
 

Husband of

Senior Member
Messages
313
Darn just An abstract . Alternatively polarized macrophages means anti rather than pro inflammatory. So that's interesting.
 

SWAlexander

Senior Member
Messages
1,898
Abstract
A model considering alternatively polarized macrophages as a major contributor for these molecular alterations is presented.

There was one more sentence:
"One sentence Summary: Multi-omics plasma analyses demonstrate anti-inflammatory and hypo-metabolic signatures in patients with Long COVID Syndrome."
The word "hypo-metabolic" caught my attention.

Here are some frightful collected explanations:
"In humans, hypometabolism is a naturally occurring phenomenon of sleep; it appears in conditions of starvation and during hypnosis."
"Here, we report that adenosine monophosphate (AMP) triggered hypometabolic state..."
"Hypometabolism, characterized by decreased brain glucose consumption, is a common feature of many neurodegenerative diseases."
 
Last edited:
Messages
600
I think the most interresting thing from the paper though is the indications they have that the macrophages are the ones causing the anti-inflammatory activities. Why would they do that and is that causing the PCS.