Jesse2233
Senior Member
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- Southern California
Hey guys - thought it might be interesting to list out all the major ME/CFS causal theories in one place.
This can act as a primer for newbies, and as a way to look at everything in a comprehensive manner in the hopes of making fresh connections.
I’ve tried to keep each theory to one simple sentence. Let me know if I’ve left out or grossly misstated anything important.
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Enlightened GPs / laypublic - post-infectious non-specific immune dysfunction
Unenlightened GPs / laypublic - psychological construct / wastebasket diagnosis
Melvin Ramsay - polio-like illness following an enterovirus infection
John Chia - chronic non-cytolytic enterovirus infection
Byron Hyde - diffuse lower brain injury following enterovirus infection
Martin Lerner - chronic abortive herpes family infection
Kenny De Meirleir - inflammatory gut dysbiosis following tick-born illness
Jay Goldstein - post-infectious central sensitization of the brain
Jose Montoya - chronic HHV infection of the CNS
Carmen Scheibenbogen - autoimmunity against muscarinic and adrenergic receptors
Robert Naviaux - cell danger response mediated by purinergic signaling
Ron Davis / Fluge + Mella - a large molecule in serum disrupting cellular metabolism
Mark Davis - nonspecific antigen causing inflammatory T-cell dysfunction
Sarah Myhill - multicausal dysfunction of various mitochondrial mechanisms
Neil McGregor / Chris Armstrong - genetic susceptibility to gut dysbiosis causing sepsis-like metabolic state
Ritchie Shoemaker / Joseph Brewer - mold causing immune dysfunction
Jarred Younger - chronic microglial inflammation
Rich Van K / Fred Davis - blockage in glutathione production
Michael Van Elzakker - chronic infection of the vagus nerve
Martin Pall - dysfunction of the nitric oxide cycle
Garth Nicholson - chronic mycoplasma pneumonia infection
Peter Behan - enterovirus driven autoimmunity against ATP translocator
Andy Cutler - chronic heavy metal toxicity
Judy Miktovas - chronic XMRV / HERV infection
William Weir - chronic non-specific retrovirus infection
Cecil Jardin - chronic non-specific bacterial infection
Gupta / Hooper / Neuffer - non-specific autonomic dysfunction
Chalder / White / Wesely / Parker - self-limiting fear based beliefs
The 1980s - Candida
The 1990s - EBV
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Some PR theories
@necessary8 - autoantibody to CD38 causing metabolic dysfunction through eATP
@Jonathan Edwards - 6+ subtypes involving immune sensitization, autoimmunity, and chronic inflammation
@mariovitali - suboptimal liver function leading to immunological / metabolic dysfunction
This can act as a primer for newbies, and as a way to look at everything in a comprehensive manner in the hopes of making fresh connections.
I’ve tried to keep each theory to one simple sentence. Let me know if I’ve left out or grossly misstated anything important.
——————————
Enlightened GPs / laypublic - post-infectious non-specific immune dysfunction
Unenlightened GPs / laypublic - psychological construct / wastebasket diagnosis
Melvin Ramsay - polio-like illness following an enterovirus infection
John Chia - chronic non-cytolytic enterovirus infection
Byron Hyde - diffuse lower brain injury following enterovirus infection
Martin Lerner - chronic abortive herpes family infection
Kenny De Meirleir - inflammatory gut dysbiosis following tick-born illness
Jay Goldstein - post-infectious central sensitization of the brain
Jose Montoya - chronic HHV infection of the CNS
Carmen Scheibenbogen - autoimmunity against muscarinic and adrenergic receptors
Robert Naviaux - cell danger response mediated by purinergic signaling
Ron Davis / Fluge + Mella - a large molecule in serum disrupting cellular metabolism
Mark Davis - nonspecific antigen causing inflammatory T-cell dysfunction
Sarah Myhill - multicausal dysfunction of various mitochondrial mechanisms
Neil McGregor / Chris Armstrong - genetic susceptibility to gut dysbiosis causing sepsis-like metabolic state
Ritchie Shoemaker / Joseph Brewer - mold causing immune dysfunction
Jarred Younger - chronic microglial inflammation
Rich Van K / Fred Davis - blockage in glutathione production
Michael Van Elzakker - chronic infection of the vagus nerve
Martin Pall - dysfunction of the nitric oxide cycle
Garth Nicholson - chronic mycoplasma pneumonia infection
Peter Behan - enterovirus driven autoimmunity against ATP translocator
Andy Cutler - chronic heavy metal toxicity
Judy Miktovas - chronic XMRV / HERV infection
William Weir - chronic non-specific retrovirus infection
Cecil Jardin - chronic non-specific bacterial infection
Gupta / Hooper / Neuffer - non-specific autonomic dysfunction
Chalder / White / Wesely / Parker - self-limiting fear based beliefs
The 1980s - Candida
The 1990s - EBV
——————————
Some PR theories
@necessary8 - autoantibody to CD38 causing metabolic dysfunction through eATP
@Jonathan Edwards - 6+ subtypes involving immune sensitization, autoimmunity, and chronic inflammation
@mariovitali - suboptimal liver function leading to immunological / metabolic dysfunction
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