7 Day NAD+ Infusions (Severe ME/CFS Recovery, Neurological / Mitochondrial / Genetic Repair) + POLL

What is your experience with NAD+ ?

  • I had the full NAD+ IV protocol and benefitted (7+ infusions)

    Votes: 1 1.1%
  • I had the full NAD+ IV protocol and did not benfit (7+ infusions)

    Votes: 1 1.1%
  • I had 1-6 NAD+ IVs and benefitted

    Votes: 7 7.6%
  • I had 1-6 NAD+ IVs and did not benefit

    Votes: 3 3.3%
  • I tried and benefited from nasal NAD+

    Votes: 0 0.0%
  • I tried but did not benefit from nasal NAD+

    Votes: 1 1.1%
  • I tried and benefited from oral NAD+

    Votes: 5 5.4%
  • I tried but did not benefit from oral NAD+

    Votes: 17 18.5%
  • I tried and benefited from transdermal NAD+ (patch)

    Votes: 0 0.0%
  • I tried but did not benefit from transdermal NAD+ (patch)

    Votes: 1 1.1%
  • I have not tried NAD+ but have benefited from a NAD+ precursor (NIAGEN, Niacin, B3, NADH etc)

    Votes: 11 12.0%
  • I have not tried NAD+ and have not benefited from a NAD+ precursor (NIAGEN, Niacin, B3, NADH etc)

    Votes: 14 15.2%
  • I have never tried any form of NAD+ or NAD+ precursor

    Votes: 31 33.7%

  • Total voters
    92

gbells

Improved ME from 2 to 6
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No, it sounds like experience. I'm almost 60 and NAD+ definitely increases my energy and ability to exercise.

And fact. This tutorial explains the ways that NAD+ is used to make ATP.

https://content.byui.edu/file/a2369...3b3e3a640/1/module8/readings/atp_nad_fad.html
I don't think you understand the biochemistry and rationale for supplementation. NAD is used for redox reactions. Supplementation is only to restore lost capacity. It doesn't have a way to boost ATP by itself. It is supplemented in adults to restore lost function.

D-ribose is a work around that directly increases ATP capacity. A hack.

That is why people should use both.
 

Rlman

Senior Member
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I don't think you understand the biochemistry and rationale for supplementation. NAD is used for redox reactions. Supplementation is only to restore lost capacity. It doesn't have a way to boost ATP by itself. It is supplemented in adults to restore lost function.

D-ribose is a work around that directly increases ATP capacity. A hack.

That is why people should use both.
When I tried using d-ribose, my heart rate went through the roof, but no extra energy. Do you have any idea why this happened? Tnx
 

Rlman

Senior Member
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The oral version can be beneficial, but the benefits of just putting it under your tongue, and passively getting it into your bloodstream, are easier, without the risk of infection, without the unpleasant side effects, and benefits last for several hours.
Thank you, will follow your advice, so what is the best brand?
Cost is not that important.
 

mitoMAN

Senior Member
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https://pubmed.ncbi.nlm.nih.gov/17127275/
We observed that intranasal NAD+ delivery significantly increased NAD+ contents in the brains.
The NAD+ administration also significantly attenuated ischemia-induced neurological deficits. In contrast, intranasal administration with 10 mg/kg nicotinamide did not decrease ischemic brain damage.

These results provide the first in vivo evidence that NAD+ metabolism is a new target for treating brain ischemia, and that NAD+ administration may be a novel strategy for decreasing brain damage in cerebral ischemia and possibly other PARP-1-associated neurological diseases.
 

livinglighter

Senior Member
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Oral NAD+ works very well for me. D-ribose stopped working alongside my condition getting worse. I've yet to try both together.

I do also take magnesium bisglycinate which seems to have moved me back up the severity scale.
 

Learner1

Senior Member
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I don't think you understand the biochemistry and rationale for supplementation. NAD is used for redox reactions. Supplementation is only to restore lost capacity. It doesn't have a way to boost ATP by itself. It is supplemented in adults to restore lost function.

D-ribose is a work around that directly increases ATP capacity. A hack.

That is why people should use both.
You have no need to insult my knowledge of biochemistry. NAD is also a cofactor for several reactions.

I have used both d-ribose and NR at high doses in multiple trials for 2 months at a time. Neither work at all for me, I believe due to mutations on my NMRK1 and 2 genes.

Both NAD+ and NMN give a very positive effect within. 10 minutes. I find NR to be an overly hyped waste of money and d-ribose to be a sugar sweetener for beverages, but not an ATP producer.
 

livinglighter

Senior Member
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When I wasn't so bad d-ribose worked well for me. I had one of my worst relapses which included a hypoglycemic episode, severe chest pain, etc. symptoms I've never experienced during a relapse before. After that d-ribose stopped working. I tried NR, it worked for mental fatigue, but I still had heavy limbs and slow movement, etc. I started to revisit my notes from a chartered physiotherapist with ME specialism and they advised I take magnesium. I almost immediately moved back up the severity scale. I can tolerate more physical and mental exertion, have improved sleep and less PEM (either none or mild PEM).

On @Learner1 suggestion and perhaps a few others I tried NAD+ and I had an instant very high energy boost. It was perhaps a little too high, as I managed to do all the Xmas cooking and was up all night. I don't have the same rush when I take it now though. Without NAD+ I'm not sure where I would be energy-wise right now.

I take alive by nature NAD+.
 

gbells

Improved ME from 2 to 6
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I don't mean to insult you but you can't apply a rare biochemical mutation to everyone. For most people it will go as I said.

I have used both d-ribose and NR at high doses in multiple trials for 2 months at a time. Neither work at all for me, I believe due to mutations on my NMRK1 and 2 genes.
 

gbells

Improved ME from 2 to 6
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Not sure they're that rare, but most people don't know what genes they have. The NMN and NAD+ are more direct and should work on almost everyone.
NMN and NAD+ have much worse absortion than Nicotinamide Riboside (NMR) which is why it is preferred. As long as the person can do the conversion normally NMR works better for that reason and is preferred. Also, even if you have the defect adults lose their conversion ability over time so it is pointless to supplement NMN and NAD+.
 
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livinglighter

Senior Member
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Thanks, but how were you taking it, by rinsing in the mouth?
The powder comes with a scoop. I place the powder under my tongue until it dissolves completely, then swallow.

The tablets are easier and have a special coating and added flavouring. Place under the tongue until it dissolves completely, then swallow.
 

Thomas

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A friend of mine is doing subcutaneous NAD+ injections prescribed by his doctor. It is 0.20 ml (or 20 units in a diabetic needle) daily. It’s helping a lot although he doesn’t have full blown ME/CFS.
wondering if anyone here is still experimenting with SQ injections and/or IV and how that’s going. Also are there any reputable online pharmacies that carry injectable NAD+ one could recommend, if any?

Oral does of NAD+ or NADH don’t do much for me. Would you suggest starting with SQ injections before IV to see how you tolerate it? Or is IV the best starting point if you want to know relatively quickly if NAD+ is helping you or not?
 

Lieselotte

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@Thomas I would say doing an IV is the fastest way to get a read on whether NAD is going to be helpful for you (you should know right away as soon as the IV is done). Just a low dose, depending on how severe you are, no more than 250mg.
Then maybe you can play around with subQ and see if you can get a good response that way too.
 

Thomas

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@Thomas I would say doing an IV is the fastest way to get a read on whether NAD is going to be helpful for you (you should know right away as soon as the IV is done). Just a low dose, depending on how severe you are, no more than 250mg.
Then maybe you can play around with subQ and see if you can get a good response that way too.
Thank you. Out of curiosity just so I can be as clear with the infusion center as possible: How is the NAD+ administered via the IV? Is it mixed into saline and if so how much or is just the NAD+ that is dripped through the IV without being mixed into anything?