Jesse2233
Senior Member
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I've been researching NAD+ IVs extensively in the last few days. NAD+ is of course a crucial co-factor in cellular metabolism, and one that is plausibly deficient in many ME/CFS patients.
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The full NAD+ infusion protocol is 7-12 days of 1500mg 8 hour infusions. This is said to replenish deficient levels, and nasal supplementation can then be continued as maintenance.
Research at Harvard is being done to see if therapeutic NAD+ can repair neurological damage in Parkinson's and ALS
There are also studies looking at its ability to restore normal mitochondrial function, reverse autoimmunity, and repair genetic damage.
It seems to be another protocol that few ME/CFS patients have tried in full (due to limited availability, high cost ~$10-20k, and large time commitment).
I've included a poll to see if anyone here has had it. Please select your most successful outcome.
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Here's an interesting primer by a South African doctor named Theo Verwey on NAD+'s therapeutic use.
Here is an interview with a severe CFS patient named Thomas (bedridden, ill 7 years) who recovered fully. I have personally spoken to him, his story is real.
He had 7 days of high dose IV NAD+, with additional maintenance. Since recovering he ran and placed in the top 10% of a Spartan Race (high endurance with obstacles).
The interview also includes Dr. Philip Milgram, MD (who uses NAD+ in addiction), and Dr Ross Grant, PhD (a leading NAD+ researcher).
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It has also been shown that NAD+ levels prompt exit from dauer state in c elegans (of importance due to Dr Naviaux's dauer / hypometabolic theory).
More discussion of that here: http://forums.phoenixrising.me/inde...that-promotes-exit-from-dauer-diapause.57363/
-------------------
The full NAD+ infusion protocol is 7-12 days of 1500mg 8 hour infusions. This is said to replenish deficient levels, and nasal supplementation can then be continued as maintenance.
Research at Harvard is being done to see if therapeutic NAD+ can repair neurological damage in Parkinson's and ALS
There are also studies looking at its ability to restore normal mitochondrial function, reverse autoimmunity, and repair genetic damage.
It seems to be another protocol that few ME/CFS patients have tried in full (due to limited availability, high cost ~$10-20k, and large time commitment).
I've included a poll to see if anyone here has had it. Please select your most successful outcome.
---------------------
Here's an interesting primer by a South African doctor named Theo Verwey on NAD+'s therapeutic use.
- He puts CFS under the umbrella of a condition called NED (NAD Energy Deficiency)
- He claims that one can measure their "Energy Value" via a formula involving lactate to pyruvate ratio. And that Energy Values below 100 indicate a need for therapeutic NAD+
Take the lowest score of the following:
(Pyruvate value x 1000) ÷ Lactate value
or
If Pyruvate Value is between 0 to 0.048 then Pyruvate Value ÷ 0.0003
If Pyruvate Value is 0.049 and greater then 8 ÷ Pyruvate Value
or
If Lactate Value is between 0 to 1.00 then Lactate Value ÷ 0.005
If Lactate Value is 1.01 and greater then 220 ÷ Lactate Value
- He says 7-12 weeks of intensive NAD+ treatment are needed to restore depleted levels with supplementation continuing afterwards
Here is an interview with a severe CFS patient named Thomas (bedridden, ill 7 years) who recovered fully. I have personally spoken to him, his story is real.
He had 7 days of high dose IV NAD+, with additional maintenance. Since recovering he ran and placed in the top 10% of a Spartan Race (high endurance with obstacles).
The interview also includes Dr. Philip Milgram, MD (who uses NAD+ in addiction), and Dr Ross Grant, PhD (a leading NAD+ researcher).
-------------------------
It has also been shown that NAD+ levels prompt exit from dauer state in c elegans (of importance due to Dr Naviaux's dauer / hypometabolic theory).
More discussion of that here: http://forums.phoenixrising.me/inde...that-promotes-exit-from-dauer-diapause.57363/
