Heterozygous MTHFR C677T reduces methylfolate production to 65% of normal, and A1298C combined with it can reduce it to 30% of normal. SHMT1 can also have an impact on making MTHFR C677T worse, so your methylfolate production could be in pretty bad shape.
With your MTR and MTRR problems (A664A risk is reported backwards by Yasko and Geneticgenie) B12 production may also be a problem.
BHMT and CBT C699T might be causing mild problems with elevated homocysteine, but maybe not, as they're both heterozygous and neither has a big impact. If that is a problem, B6 might help.
Slow MAOA and slightly slow VDR might result in less tolerance for methyl groups. Hence hydroxoB12 may be the safer form, compared to methylB12, especially if trying higher doses.
SUMMARY:
Methylfolate and B12 supplementation are probably needed. It's also possible that normal dose of B6 would be helpful.
With your MTR and MTRR problems (A664A risk is reported backwards by Yasko and Geneticgenie) B12 production may also be a problem.
BHMT and CBT C699T might be causing mild problems with elevated homocysteine, but maybe not, as they're both heterozygous and neither has a big impact. If that is a problem, B6 might help.
Slow MAOA and slightly slow VDR might result in less tolerance for methyl groups. Hence hydroxoB12 may be the safer form, compared to methylB12, especially if trying higher doses.
SUMMARY:
Methylfolate and B12 supplementation are probably needed. It's also possible that normal dose of B6 would be helpful.
Any idea how long it would take for methylfolate and b12 supplementation to take an effect for someone in my situation?? So far I havent seen much of a positive effect... I seem to have a slight mild headache on short occassions during the day that has sprung up, but nothing serious...