• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

xenon

  1. frozenborderline

    Treatments that help attenuate opioid tolerance

    Opioids/opiates, specifically mu opioid agonists (occasionally delta) can be an important part of pain treatment and also help other me/cfs symptoms, such as insomnia or PEM. But they cause rapid tachyphylaxis (development of tolerance). This thread will be a long one in which we discuss all...