• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    Niacin and PDE5 inhibitors

    One of the supplements that has helped me a lot has been niacin (B3). It seems to reduce most of my symptoms somewhat but importantly it reduces my pain so much that it sometimes eliminates it completely. The relief can happen quite fast after taking the supplement (how fast NAD+ synthesis from...