• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. M

    Could I easily make my own topical midodrine cream?

    I have midodrine pills (5mg), but do not want to take it orally anymore. I want to make what this paper is proposing: https://jamanetwork.com/journals/jamadermatology/fullarticle/2290938 "Midodrine, 0.2%, in a moisturizing skin cream (Vanicream) was compounded at the Mayo Clinic pharmacy and...
  2. M

    Addressing blood pooling

    Vascular dysregulation has been one of my most pressing Long covid symtoms. The worst part about it is the blood pooling in my feet. In the beginning I could sit up to work without issues. Around one year into the illness, I had one episode where I believe I overexerted myself, mainly my legs...
  3. Jenny TipsforME

    Midodrine and Lying Down

    I started taking midodrine yesterday. I'm after input from people who have ME and POTS and take midodrine. When you take it you're not meant to lie down for 4 hours. Now for me that's quite a long time to not lie down/put my feet up. Does taking midodrine at the right dose take away the need...
  4. Kyla

    Midodrine hydrochloride in symptomatic orthostatic hypotension: a double-blind, placebo-controlled, randomized, tilt-table study

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951503/ (open access)
  5. S

    How to take midodrine for POTS and still take a daily nap?

    My 23-year old daughter was diagnosed with neuropathic POTS. She tried Florinef, at 1/4 of the smallest dose, and she took it in the mornings, but she had terrible insomnia from it. It also took about 2 weeks for those side effects to fully go away. Her doctor recently prescribed midodrine...
  6. S

    Midrodine: how long did it take you to ramp up the dose?

    I've been prescribed midrodine for NMH and started off at 2.5mg plus sodium tablets, 3 times a day. That dose had no effect on my BP or symptoms after ten days so yesterday I was told to increase the midrodine to 5mg, 3 times a day. It didn't do much for my BP but it did seem to improve my...
  7. Gingergrrl

    Has anyone had Midodrine make them sedated like a sleeping pill?

    I couldn't find a thread on this particular aspect of Midodrine and really wanted to get some feedback. I was started on Midodrine by my new cardiologist in the hospital, first at 2.5 mg 2x/day and now at 5 mg 2x/day. The goal was to raise my BP (which is in the 80's/50's without Midodrine)...