ido metabolic trap

  1. nerd

    The immunological inconsistency in the IDO trap theory

    There is one thing in the IDO theory I can't figure out - the inconsistent piece that actually makes me suspect that there is something more complex going on. Here is the story, extending what I wrote in the original IDO post, if you aren't familiar with the Ron Davis research yet. As a...
  2. nerd

    Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms

    Vancassel S, Capuron L and Castanon N (2018) Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms. Front. Neurosci. 12:499. doi: 10.3389/fnins.2018.00499 Abstract How is this relevant? One of the unsolved questions of...
  3. dreamydays

    Escaping the metabolic trap (IDO)

    I still think the metabolic trap theory has some merit. Robert Phair looked into genetic problems and his current theory is that tryptophan metabolism gets overloaded and we don't have the ability to process it and so we get stuck in a trap. The enzyme which can process it is IDO1, as we lack...
  4. necessary8

    The RBC-NOX hypothesis

    The RBC-NOX hypothesis Hello again, everyone. Welcome, to the RBC-NOX hypothesis, which I consider by far my best idea yet. It connects the IDO metabolic trap, red blood cell deformability, craniocervical instability (including recoveries after surgery), Alan Light’s research on fatigue...