• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. T

    Female hormone help

    So which hormone is the one that causes heavy bleeding? Estrogen or Progesterone? Also what do these numbers represent? Is this within normal ranges or do they indicate Estrogen dominance? Thank you! The ratio of estradiol to progesterone is 227 pmol/L estradiol to <0.5 nmol/L progesterone
  2. M

    Should blood volume be considered when interpreting test results?

    This is very much a layman’s question. I’ve read that blood volumes in ME/CFS patients with POTS can be substantially lower than normal. I would like to know whether reduced blood volume directly reduces the effective “dose” of agents that are carried in the bloodstream, such as thyroid...
  3. Joel98

    Can I try 5-HTP despite the possible Metabolic Trap without irreversibly worsening it?!

    Hello, I'm wondering if I can test 5-HTP capsules without worsening the possible Metabolic Trap. If I understand it correctly, it is still unclear whether you have too much or too little serotonin as a result. My symptoms tend to feel like too little and a urine test (which I know has little...
  4. Pyrrhus

    Hormones in the body: where they come from, and where they go to

    Hormones in the body: where they come from, and where they go to I found this great diagram courtesy of @halcyon :
  5. Celandine

    Why Women are More Prone to Long Covid (and ME/CFS)

    Good piece in the Guardian looking at various theories. Very applicable to ME, as well. One of the things it says is "Some scientists have already begun to describe long Covid as an oestrogen-associated autoimmune disease..." which is very interesting and not something I've seen mentioned...
  6. Joel98

    Questions about the drug Clomid for low LH, Fsh, testosterone, estradiol levels in context to ME/CFS

    Hello, I am a male, 22 years old, ME/CFS for 3 years, Bell scale 20-30. I would like to test Clomid / Clomiphene because of my low LH, Fsh and decreased testosterone, free testosterone, estradiol levels, prolactin is borderline high. Coherently I have most of the time decreased erythrocytes...
  7. thingsvarious

    I replace ALL my hormones. This brought me back to life. But is it sustainable for decades?

    In my opinion CFS is often (not always obviously) multiple hormone deficiency (esp. adrenals, perihperal thyroid sensitivity). I am a medical student in my last year. I replace ALL of my hormones. my energy levels went from the 5th percentile to the 95th percentile. In early twenties my life...
  8. Sarah94

    Klimas' models of ME/CFS

  9. M

    Low thyroid (t3) a result of CFS? And, does supplementation help?

    As CFS'ers, are we more prone to lower thyroid levels, specifically t3 (and maybe t4), especially the longer we are ill? And if the CFS is the cause of the lower hormone levels, does supplementation do anything? I also read an article that people who have chronic illnesses often develop lower...