exercise intolerance

  1. C

    Neurovascular Dysregulation and Acute Exercise Intolerance in ME/CFS: A Randomized, Placebo-Controlled Trial of Pyridostigmine (Joseph et al, 2022)

    Authors Phillip Joseph, Rosa Pari, Sarah Miller, Arabella Warren, Mary Catherine Stovall, Johanna Squires, Chia-Jung Chang, Wenzhong Xiao, Aaron B. Waxman, David M. Systrom, Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by intractable...
  2. Pyrrhus

    Cardiopulmonary, metabolic, and perceptual responses during exercise in ME/CFS: A Multi-site Clinical Assessment of ME/CFS sub-study (Cook et al 2022)

    Cardiopulmonary, metabolic, and perceptual responses during exercise in ME/CFS: A Multi-site Clinical Assessment of ME/CFS sub-study (Cook et al., 2022) https://doi.org/10.1371/journal.pone.0265315 A study that provides more evidence of exercise intolerance in ME, and evidence that this...
  3. Pyrrhus

    Exercise Intolerance vs. PEM/Exertion Intolerance

    Exercise Intolerance vs. Exertion Intolerance vs. PEM A common source of confusion are the terms "exercise intolerance" and "exertion intolerance", and how they relate to PEM. So here's a brief clarification: Exercise Intolerance is a medical term that refers to the inability to perform...
  4. SWAlexander

    Exercise Intolerance in Hypermobility: Systemic Vascular Distensibility relates to exercise capacity in connective tissue disease (Singh et al 2021)

    A Similar Kind of Exercise Intolerance is Found in Connective Tissue Diseases, ME/CFS and Long COVID Results The study found that the blood vessels of people with CTD did not dilate as much as the healthy controls. The CTD patients also displayed an “impaired stroke volume increase”. As their...
  5. Pyrrhus

    Orthostatic Intolerance (OI) Basics: Dysautonomia of Blood Vessels, Low Blood Volume, and Baroreflexes

    I just read a good overview article covering all the basics of orthostatic intolerance: Common Syndromes of Orthostatic Intolerance (Stewart, 2013) https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3639459/pdf/peds.2012-2610.pdf (or https://dx.doi.org/10.1542/peds.2012-2610) This paper starts...
  6. Pyrrhus

    Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post–Coronavirus Disease (Mancini et al., 2021)

    Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post–Coronavirus Disease (Mancini et al., 2021) https://doi.org/10.1016/j.jchf.2021.10.002 A study by Ben Natelson and colleagues that confirmed the key findings from David Systrom's iCPET study on Long Covid patients...
  7. M

    Long Covid research- persistent dyspnea and exercise intolerance

    I noticed that Dr. David Systrom published a paper that resonates a lot with what I have been experiencing. Persistent Exertional Intolerance after COVID-19: Insights from Invasive Cardiopulmonary Exercise Testing. https://journal.chestnet.org/article/S0012-3692(21)03635-7/fulltext They...
  8. Pyrrhus

    Cardiopulmonary Exercise Test (CPET) Methodology for Assessing Exertion Intolerance in ME/CFS (Stevens et al., 2018)

    I don't think this paper has been posted yet, but it's a good review of the studies that look at CardioPulmonary Exercise Tests (CPET) to document PEM/exertion intolerance in ME. Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in ME/CFS (Stevens et al., 2018)...
  9. Diwi9

    Interview with Dr. David Systrom (May 5, 2020) on exercise intolerance

    Video interview with Dr. Systrom entitled: "Pathophysiology of Exercise Intolerance in Chronic Fatigue Syndrome"
  10. Kyla

    Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing

    This isn't about ME, but some of the patients had POTS, and this is discussed in the context of exercise testing. Thought the results might be of interest to some here. I have pulled out one of the relevant sections and quoted it (below the abstract)...