• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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david systrom

  1. mitoMAN

    New Systrom Study: PPAR Delta for ME/CFS

    https://clinicaltrials.gov/ct2/show/NCT04855201 A Study to Evaluate ASP0367 in Participants With Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction https://www.mitobridge.com/about/science/ Interesting new trial by Dr Systrom in collaboration with Mitobridge. Why...
  2. C

    Neurovascular Dysregulation and Acute Exercise Intolerance in ME/CFS: A Randomized, Placebo-Controlled Trial of Pyridostigmine (Joseph et al, 2022)

    Authors Phillip Joseph, Rosa Pari, Sarah Miller, Arabella Warren, Mary Catherine Stovall, Johanna Squires, Chia-Jung Chang, Wenzhong Xiao, Aaron B. Waxman, David M. Systrom, Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by intractable...
  3. SWAlexander

    Exercise Intolerance in Hypermobility: Systemic Vascular Distensibility relates to exercise capacity in connective tissue disease (Singh et al 2021)

    A Similar Kind of Exercise Intolerance is Found in Connective Tissue Diseases, ME/CFS and Long COVID Results The study found that the blood vessels of people with CTD did not dilate as much as the healthy controls. The CTD patients also displayed an “impaired stroke volume increase”. As their...
  4. M

    Any Dr. Systrom patients here? - Mestinon (Pyridostigmine bromide) and safety profile

    Hello, So I got a prescription for Mestinon from my doctor to see if it helps with exertional intolerance (most notably pain/discomfort after exercise). I am freaking out about it though. For those that are not aware, this drug has been linked as a causal factor in Gulf War Illness (GWI). This...
  5. M

    Long Covid research- persistent dyspnea and exercise intolerance

    I noticed that Dr. David Systrom published a paper that resonates a lot with what I have been experiencing. Persistent Exertional Intolerance after COVID-19: Insights from Invasive Cardiopulmonary Exercise Testing. https://journal.chestnet.org/article/S0012-3692(21)03635-7/fulltext They...
  6. Pyrrhus

    Exercise Intolerance: Insights from Invasive Cardiopulmonary Exercise Testing of Patients with ME/CFS (Joseph et al., 2021)

    A new publication by the team of Phillip Joseph, Anne Oaklander, and David Systrom, which I personally find exciting. Insights from Invasive Cardiopulmonary Exercise Testing of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Joseph et al., 2021)...
  7. Pyrrhus

    Presentations from Ron Tompkins, David Systrom, Donna Felsenstein (courtesy OMF & Massachusetts ME/CFS/FM Association)

    Massachusetts ME/CFS & FM Association and Open Medicine Foundation Fall 2020 Event on Zoom October 24, 2020 Video 2: Presentation by Ron Tompkins and Q&A Video 3: Presentation by David Systrom Video 4: Presentation by Donna Felsenstein Video 5: Panel Discussion...
  8. Diwi9

    Interview with Dr. David Systrom (May 5, 2020) on exercise intolerance

    Video interview with Dr. Systrom entitled: "Pathophysiology of Exercise Intolerance in Chronic Fatigue Syndrome"
  9. Kyla

    Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing

    This isn't about ME, but some of the patients had POTS, and this is discussed in the context of exercise testing. Thought the results might be of interest to some here. I have pulled out one of the relevant sections and quoted it (below the abstract)...