acyclovir

I'm due to start Acyclovir and from researching it seems most antivirals cause some degree of Mitochondrial Toxicity. Is there a way to avoid or negate these toxicity side effects? From this table there's a host of effects from Acyclovir: Source...

I just started taking acyclovir a few days ago, now been on it for 4 days. I have had a severe worsening of symptoms. Probably the worst I have felt since getting ill. Does anyone else have experience with this? Could this be due to the acyclovir? Is it some sort of die off reaction?