Search results for query: memantine

...to stimulate Gaba receptors sensitivity and reduce the glutimate and NMDA excitation. ( in a similar way for the NMDA blocking effect of memantine plus some gaba affect too) Where nicotine is said to do the opersites. Therefore I’m quite interested in it from a double perspective or even...

Thank you too for sharing your experimentations! You make me feel sarcosine might help me, I will try it :thumbsup:

...schizophrenia. I might try D-serine next but it’s harder to find. I find that medications and supplements that lower NMDA activity (like memantine, oxaloacetate, and agmatine) make me feel very depressed. Ones that increase activity make me feel better but more emotionally blunted. Thank you...

...I did high doses without effect, but now Im trying your approach with smaller doses with Vit C during whole day. Will see! I also bought Memantine and Amantadine yesterday - if I understand correctly, it has a chance to do some good effect for me. Any experiences with this drugs? I also...

I'm completely uneducated when it comes to this gaba / glutamate / excitotoxicity type of thing. But from just googling glutamate excititoxicity and the mention of loss of neural function and cell death, it all sounds rather dramatic and hopeless :aghhh:. Is that what you are saying you think...

...on what to try thats safer than clonazepam long term. clonazepam is quite dependence forming. there are gabapentinoids and ketamine and memantine and a buncha other things affecting that system in a way that is less dependence forming. so yeah... you may be able to find a doctor to help...

@judyinthesky If you do a search for 'memantine', you'll unearth a multitude of threads and mentions that might give you more of the info you're looking for .... ‘memantine’ search (without the quote marks) https://forums.phoenixrising.me/search/629939/?q=memantine&o=date I agree, altho it...

I took memantine for about 6 months. It was originally prescribed by a neurologist for headaches. When I started titrating up to the full dose, I experienced really bad depression. I noticed that my anxiety disappeared, though. Since it has a half life of about 70 hrs, I found that if I took a...

This was mentioned as having anti-excitotoxicity properties in another thread. My ME specialist wasn't convinced though. Do we have other members having experience with this or any further evidence that this is working for some people with ME. I suspect a strong excitotoxicity component with...

Thank you for the link of memantine. I've stumbled across this as well. I was asking my ME specialist yesterday but he wasn't convinced. Maybe I'll open a thread on it

...you are truly high in glutamate without some kind of baseline measurement. I think if I had to recommend one particular drug, it would be memantine, since you are aiming towards being extra careful. You would need a prescription, but I think a neurologist (for example) would see it as a...

...sufficiently blocks glutamate or calcium channels can prevent excitotoxicity. Plenty of drugs do that - gabapentinoids, NMDA antagonists, memantine (if you need an authority, here's a good link explaining memantine's anti-excitotoxic properties). However, excitotoxicity is only one subtype of...

...seems like you're already familiar with the major ones - benzos and other GABAergics, gabapentinoids, etc. I think someone else mentioned memantine, which I think is great. I've been taking it for quite a while and it definitely reduces my pain and hyperacusis. It's an NMDA glutamate...

Thank you Technically I don't have anxiety, I have nervous system high to extremes and dissociation Thank you so much for the list, a lot I've tried already, and can't take, but memantine I've heard now a couple of times.. as off Label idea for ME as well. Any experience welcome.

...regimen, and see I lose weight. It says here: Bromocriptine and cabergoline are not the only dopamine agonist drugs; you also have: Memantine — dopamine D2 agonist (as well as an NMDA blocker). Ropinirole — acts as a D2, D3 and D4 dopamine receptor agonist with highest affinity for D2...

A few things that might be helpful to look into. Memantine is a drug that some have found helpful at reversing benzo tolerance or atleast reducing tolerance issues. It may help reduce tolerance to alternate between different benzos, but would have to work out a time frame with your dr as some...

Thanks for the detailed post with so much useful information. It's funny you mentioned Phenibut. A few years ago, when I had some initial symptoms but not full blown M.E., one of the first issues I had was dehydration/inability to retain fluids/always extremely dry/thirsty. I was just about...

...helped my nervous system too but can't be used regularly without tolerance. : ideas for alternatives: any safe nmda antagonist --ketamine, memantine, xenon (expensive but safe)... iv or injected magnesium (more mild but worth a try), progesterone (@Hip has it in his nmda antagonist thread )...

...ADHD, which is also characterized by decreased dopaminergic signaling). I haven't personally tried either of those drugs, but I do take memantine, which is a D2 agonist, though it has many of other mechanisms which could be causing some benefit for me. I wonder if there are any drugs which...

does it help with brain fog? are you planning on stopping it?

!Memantine has hekped me a lot but unfortunately causes constipation issues

...opioids. IV lidocaine, IV magnesium, some supplements like quercetin, gabaoentin, ketamine , oxytocin (the hormone, not the narcotic ), memantine,those are all interesting ideas but you can't just assume theyll aork, opioids are a bit simpler and more time tested. Anyway , request for help...

There has been some talk on memantine before on the forum, so a forum search might reveal members who have used it.

Additionally does memantine cause worsened tachycardia or issues with POTS,bc it seems to for me, although maybe one gains tolerance to those effects

I use both agmatine and memantine to keep opioid tolerance reasonable or low. And to prevent hyperalgesia. (I also use ultra low dose naltrexone at the same time but I dont think that has any interactions) Memantine has fairly well documented mechanism of action and side effects and human...

H.m yeah I guess I was just wondering what you know about the pharmacology respectively and if you think that shows any clues to negative interactions. I'll ask the dr who prescribes memantine , but shes not very responsive

I would not know, unfortunately, I have had little experience of either.

@rpapen77 @sb4 @Iritu1021

@Hip Any negative interactions btwn agmatine and memantine????

...there for trying to keep my opioid tolerance reasonable so it could be theoretically replaced by uldn if we find a pharmacy to do that. Or memantine. @Hip wondering what you think of this issue in general but also what you think of the supplement stack, including agmatine , and whether...