Search results for query: Mifepristone

any indication/consideration/speculation of whether the low cortisol was there before the illness as well?

...Dr. Klimas’s model-generated protocol for Gull War Illness (GWI) and ME/CFS includes both an immune modulator (etanercept) and drug (mifepristone) that she hopes will reset the HPA axis. https://www.healthrising.org/blog/2022/08/03/predictive-long-covid-factor-chronic-fatigue-fibromyalgia/

...fluoxetine and fluvoxamine), calcium channel blockers (eg, verapamil and diltiazem), steroids and their modulators (eg, gestodene and mifepristone), and several herbal and dietary components. The inactivation of CYP3A4 by drugs often causes unfavorable and long-lasting drug-drug interactions...

...using a couple of drugs one of them being entanercept, an injectable drug that has been used in Rheumatoid Arthritis and Psoriasis, and mifepristone. I recall it was successful and she was going to do a similar trial on me cfs believing there was a similarity in the diseases. That was a...

https://nova.zoom.us/webinar/register/WN_gGavNG9SRgSsdh8KGdq_9g It appears Nancy Klimas will be giving an update on her research. Hopefully she will be discussing the preliminary results of her Phase I study on Etanercept/Mifepristone in GWI. Looks like you need to register for the webinsar.

Hey @Hip appreciate your thoughts on this. Sorry it took awhile to get back here. Yeah good to hear you don't think it was an overdosaging then. I also agree it's likely more an overly off track HPA axis response as well. I think the combo of doing the GH while also being under stress and...

...be a gentle attempt at getting the HPA axis to try to return to normal. There is also a risky HPA axis reset you can do with the drug mifepristone, but I would be wary of that. If you =Hip&o=date']search my posts for mifepristone, you will see my own rather negative experiences with...

Fuck, you got balls.

...if your doctor is convinced enough that it is worth a try you can try it. I have tried Nancy Klimas's protocol in full (Etanercept and Mifepristone) but it did not work. I tried Copaxone (generic called Glataxone) but that also did not work. So I hope you get the point. Dont loose heart...

...also by dr Alan light) and FOXO1A FOXC1 has association with breast cancer among others as it’s a tumour suppressor https://www.ncbi.nlm.nih.gov/m/pubmed/29487724/ FOXC1 target genes https://academic.oup.com/hmg/article/17/4/490/2355979 Mifepristone used to stimulate reaction

I don't think you can achieve the same result with a high dose of cortisol followed by a stop because of the unique properties of mifepristone. I had a theory that mifepristone might not cross the blood brain barrier well and that seems to be the case from research I've done. So it causes...

@nandixon Mifepristone is a cortisol antagonist, and the protocol seems to use it for this property. (Mimicking a drop of cortisol stimulates ACTH production) But this may be achieve the same way by taking a high dose of cortisol followed by a stop, which would first suppress the HPA axis...

I am betting on suramin not paying off, and the mechanism of action behind it is pretty speculative, funding is also obvious problem with the suramin trial. If naviaux , who is brilliant, had more money for his autism research, he may have had larger autism trials, more press, etc, snowballing...

...serendipitously? Even one of the agents currently being looked at (suramin, CT38, SS31/elamipretide, copaxone, Nancy Klimas' etanercept/mifepristone combo, or one of the several natural agents Jarred Younger is testing) may prove to be helpful, whether somewhat or dramatically. Throwing more...

Thanks for this information Nandixon; much appreciated. Is there no way to get a tiny clue as to if her protocol is having results? After all, the folks aren't going to be on these meds for long periods of time. And how many CFS patients are in her trial? Thanks.

I'm pretty sure that the same drug combination I previously mentioned (etanercept + mifepristone) that Klimas is currently using in her two clinical trials for GWI men and postmenopausal ME/CFS women is what worked in the GWI mice. And again, the etanercept would be replaced with an (still to...

...post-menopausal women, that she's using a two-stage treatment protocol of etanercept first to target the immune system followed by mifepristone to reset the HPA axis. (Note that while mifepristone may end up being useful for a number of different subgroups, etanercept on the other hand would...

...because cytokine levels are always fluctuating and the ranges for "normal" are really wide. I don't know what the deal is with the mifepristone as the other component of her treatment, and can't claim to have the background to evaluate it. After briefly looking into it, I'm still a little...

...trying right now is just an attempt to dampen down “inflammation” (i.e., modulate pro- and anti-inflammatory cytokines in a hopefully favorable direction) as a prelude to trying to do a reset of the HPA axis with mifepristone (RU486) per Nancy Klimas's work. Thanks for posting your experiences.

Is there any news available about her trials? Awfully quiet from that corner.

...both a subgroup of GWI men and a group of postmenopausal ME/CFS women using a two-step sequential treatment of etanercept followed by mifepristone to first dampen down proinflammatory cytokines and then reset the HPA axis (which is what the computer models for those particular subgroups...

There is a post here which compares the mechanism of Cortene to the similar mifepristone protocol used by Dr Nancy Klimas (which I hope is correct).

...trial she's doing for postmenopausal ME/CFS women is apparently going to use the same sequential protocol of etanercept followed by mifepristone that's being used right now for the clinical trial for men with Gulf War Illness (GWI). She (or her staff) has said at least a couple of times in...

DEL

The treatment is pretty short. 4 weeks of etanercept + 1 week of mifepristone + 8 weeks of observation = 13 weeks = 3.25 months. Though on the graphic below (where I got the info) it says a total of 16 weeks. She's mentioned in a video that she's had 1 GWS patient go through and said that...

Okay, another link for the Gulf War Illness Clinical Trials and Interventions Consortium for research with funding of $5MM https://cdmrp.army.mil/search.aspx?LOG_NO=GW170044

There is some info on this government site updated on Nov 13th https://cdmrp.army.mil/gwirp/research_highlights/18klimas_highlight On the NOVA site the phase I and phase II trials are listed under "Gulf War Illness Consortium" which is a separate section from the COQ10 etc. Maybe reporting is...

...fall. In addition, in her talk late summer she said she hoped to start the men study by christmas. I can't find any of these CFS studies on clinicaltrials.gov, neither the GWS study with the etanercept and mifepristone, which I find weird (the glutathione/curcumin and CoQ10 studies are there)...

...trials in both GWI and in postmenopausal ME/CFS women currently underway using a two step sequential treatment of etanercept followed by mifepristone to first dampen the inflammatory process and then reset the HPA axis.) @Janet Dafoe (Rose49) (Not sure if Ron Davis might be interested in this.)