Search results for query: mestinon

...work at all. HCSE and Butcher's broom also did not help either. The things that help me increase a little bit the tolerance to sitting are Mestinon or Midodrine. However, it is nowhere close to where I want to be. I can't rely on them to work full-time. What can I do to help reverse the...

I have been taking Mestinon during the last three weeks (120 mg/day) with no effect on my symptoms. In view of this, my doctor (who is not familiarized with MECFS or POTS) thinks that I should give up on the treatment. However, I am not sure and I wonder if only three weeks is enough time to...

Hello, So I got a prescription for Mestinon from my doctor to see if it helps with exertional intolerance (most notably pain/discomfort after exercise). I am freaking out about it though. For those that are not aware, this drug has been linked as a causal factor in Gulf War Illness (GWI). This...

I took 20mg of mestinon. and now I have intense muscle twtitching all over my body. My whole body are twitching quite intensely. and my tongue is effected too, idk how, It makes it difficult to speak. my tongue isnt numb, but almost feel like it I think I experienced this a few months back...

Hi guys, An update on the Mestinon trial: From the desk of Ronald G. Tompkins, MD, ScD Co-Director, The Harvard ME/CFS Collaboration Mestinon Trial Update In May, 2020, Open Medicine Foundation (OMF) announced the Mestinon Clinical Trial for ME / CFS, conducted at the Brigham & Women’s...

or just POTS? or does it work for people with M.E and no OI. Also when is the Phase 3 trial due to finish?

I have very severe ME. Does anybody know if it's OK to continue supplementing Magnesium while on Mestinon? I'm currently taking 20mg X 4 a day and getting quite severe muscle twitching. I previously injected Magnesium Sulphate weekly but have recently stopped due to hearing conflicting opinions...

Muscarinic receptor-mediated pyridostigmine-induced neuronal apoptosis. Li L1, Gunasekar PG, Borowitz JL, Isom GE. 2000 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-1333, USA. Abstract Pyridostigmine is a reversible cholinesterase...

Dr.Systrom seems to have quite a success with Mestinon on his patients. I'd be interested to hear what others WHO GOT WORSE on Mestinon found to be helpful. Im also wondering if you are mild/moderate or severe and how onset of ilness was.My naive hope is to find similarities in our group and...

Hi all! I have just received prescriptions for mestinon and LDN (yay!!). Has anyone taken both of these medications? Should I start them at the same time or try one for a few months and then add the other? If I do that, which should I start with first? I would also appreciate any information...

...dyspepsia 4-5 hours after eating something that I don't tolerate. I'm really desperate as I'm afraid of getting malnourished. I'm trying Mestinon, as I have read some folks describing that it helps for grastroparesis (plus this property has been shown in a couple of studies). I took only 1...

Hi, I've been working my way up to a decent Mestinon dose. I've also had an increase in pain. This could be...from anything, or just the illness. But wondering if anyone else has experienced this as a possible side effect. I'm getting lots of muscle twitches/spasms too, but I think I read...

Just started taking Mestinon or pyridostigmine, having stomach discomfort, did your body adjust to this after taking it for awhile?

https://clinicaltrials.gov/ct2/show/NCT03674541?cond=ME%2FCFS

I would like to know if anyone has tried Mestinon before? Did it help symptoms? Any side effects? I see Dr. Systrom is a big believer in it and claims good success with his CFS patients.

...with one daily dose? My doctor wants me to divide the dosage in 4 daily dosages because of the half-life. He has little experience with Mestinon and I see that most other on this forum start with one dosage and increase to two dosages after a week (+/-). I also see that many uses 4 daily...

I'm starting Mestinon treatment in a couple of days. I'm very sensitive to medication and would like some advice concerning starting dosage from other members with experience form Mestinon. My doctor don't have any experience with this treatment, so any advice would be highly appreciated :)

...about 3 weeks ago at 120 mg, 60 mg 2 times a day. About 2 weeks into this, I come down with Bell's Palsy. Has this happened to anyone else? Mestinon is used to treat Myasthenia Gravis, an autoimmune condition, which I don't have. Recently had blood work done and Dr said I had some high viral...

A few months ago I started taking Mestinon and almost immediately I started feeling worse. I was chilled, constipated, and completely out of breath all the time. I stopped taking it a few weeks ago, and things are so much better--I had never realized what a luxury it is to be able to breathe...

I've been on Mestinon for the past month or so, and I've noticed that I have been much colder than I usually am, and I usually feel pretty darn cold! I have practically been living under and electric blanket that's turned onto its highest setting (unfortunately it doesn't go up to 11), and I'm...

A bit late, but I promised to report about Mestinon Trial (@echobravo) My new GP takes M.E. seriously. :thumbsup: Not only that, he allows me to trial Mestinon without going through a specialist which would be the normal route for this kind of off-label medication use. It works well for a...

...inhibitors , are diuretics which si used to treat HPP (hypokalemia periodic paralysis). This disease is a genetic muscle channelopathy. Mestinon (pyridostigmine) and other cholinesterase inhibitors are used to treat MG (myasthenia gravis), an auto-immune disease. Both diseases induce muscle...

...vagus nerve. In the case of the vagus nerve infection hypothesis, it may also regulate exaggerated sensory (afferent) signaling. Mestinon (Pyridostigmine) - a drug that blocks the enzymatic breakdown of acetylcholine, which is the primary neurotransmitter of the vagus nerve, especially the...

In February, I had a severe EBV flare which made all my symptoms much worse. It especially bothered my heart. As a result, I ended up tapering off of Cytomel to see if the high heart rate would resolve. It did, but it threw me into low BP, low heart rate, but I still had shortness of breath...

...by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing This conference abstract appears to be a follow-up study examining the use of pyridostigmine (Mestinon) in patients with exercise intolerance and preload failure. 78% response rate is claimed.

I saw a cardiologist last week who treats POTS and she put me on Mestinon 30 mg twice a day. I find that it causes widespread muscle pain, which I did not previously have. Also, my heart rate is between 100-135 with the minimalist activities, such as walking around my house trying to make a...

...Midodrine. It also seems to be for a specific diagnosis which I don't have. On the third hand, several people from PR have now mentioned Mestinon but no doctor has recommended it for me. It is for myesthenia gravis (which I do not have) but seems to also raise BP if I am understanding it...

I've been prescribed 180 mg Mestinon SR once/day. I will begin it when I am feeling better (flu-like symptoms presently). Does anyone have any experience with this drug?

Anyone used mestinon?? Its normally used in myasthenia gravis, a muscle weakness disorder and somehow helps them but they have found it increase growth hormone especially after exercise which they say doesnt happen in fibro, so taking mestinon before exercise helps with growth hormone and...