Search results for query: TRPM3

I wonder if the reason some feel better for a day or so when they get a cold (for me the day before) is because the virus stimulates TRPM3 ion channels. 🧐

...through the release of beta-endorphins and through restoration of a calcium channel known as transient receptor potential melastatin 3 (TRPM3). TRPM3 is a member of a family of transient receptor potential (TRP) ion channels with a vital role in calcium signaling in cells. Calcium is...

...for the money :) From same authors as the COVID paper: The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK)...

same team Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients (springer.com) Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells...

...onset, impaired natural killer (NK) cell cytotoxicity and impaired ion channel function, namely Transient Receptor Potential Melastatin 3 (TRPM3). Long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has resulted in neurocognitive, immunological...

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03297-8

pregnenolone sulfate then maybe a better idea?

Hip did the math somewhere on our discord. The concentration needed for TRPM3 restoration in vivo is toxic and a way above regular naltrexone dosages (not LDN)

Naltrexone is used with low dose most of the time, maybe higher dosage is necessary to achieve TRPM3 restoration, I don't know.

Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients (Eaton-Fitch et al, 2022) Authors: Natalie Eaton-Fitch Stanley Du Preez Hélène Cabanas Katsuhiko Muraki Donald Staines Sonya...

https://pubmed.ncbi.nlm.nih.gov/30134818/ This group have done several similar studies.

No, I actually wasn't referring to any interaction between TRPM3 ion channels and NK cells. I was referring to the cortisol (glucocorticoid) and β2 adrenergic (epinephrine) NK cell receptors. These receptors are activated by the sympathetic branch of the autonomic nervous system: Note that...

Are you referring to the TRPM3 ion channels on nk function in cfsme by NCNED? This group seem to be making inroads into research of mecfs🤞

From the study listed above: " In the present study, we aim to confirm the previous results describing an impaired TRPM3 activity in a new cohort of CFS/ME patients using a whole cell patch-clamp technique after modulation with reversible TRPM3 agonists, pregnenolone sulfate and nifedipine, "...

The australian researchers Sonya Marshall Gradisnik and Donald Staines have been looking at the TRPM3 ion channels, they think dysfunction here is whats causing me/cfs. These receptors are found through out the body and govern calcium transport to many cells but also to e.g mitochondria. Calcium...

NCNED is currently conducting eye measurements study because the eye is particularly rich in TRPM3 receptors which they know are affected in ME/CFS It involves: 1. Observations of the retina at the back of your eye using OCT (Optical Coherence Tomography) 2. Observation of pupil response to a 1...

Sometimes I am thinking that there are subgroups and sometimes I think there are different starting points but they lead sooner or later to the same track of reaction in the body. Because of the conversation here in this thread I was reminded of the TRP receptor family especially the TRPV and...

...NCNED has demonstrated impairment of a non-specific calcium (Ca2+) ion channel known as Transient receptor potential Melastatin 3 (TRPM3). Repeated experiments on natural killer (NK) cells from ME/CFS patients have shown 100% impairment in function associated with TRPM3 dependent Ca2+...

Oh wow, how about that! The thing above about the decreased TRPM3 from Coxsackie might be correct. I just found this article where they found decreased TRPM3 expression in the intestines of ME/CFS patients. https://www.scirp.org/journal/paperinformation.aspx?paperid=85005 The GI tract is...

...cells (like Coxsackievirus B4). I suppose this means there's a chance that this could result in the calcium dysregulation via the decreased TRPM3 receptors on NK cells that Pyrrhus mentioned. The CVB's cleave proteins in infected cells that can mess w/ cell surface receptors and their...

...for those syndromes/symptoms. My progesterone is elevated, I just scrolled through the discussions Pyrrhus posted and saw that it blocked TRPM3. And btw I'm not aware if there are men on this forum with elevated progesterone, maybe you guys know any causes. Triggery behaviour with regards to...

...is often linked to channelopathies: https://forums.phoenixrising.me/threads/temporary-paralysis-i-need-your-insights.44812/ There is also the TRPM3 hypothesis from Staines and Marshall-Gradisnik: https://forums.phoenixrising.me/threads/ion-channel-snp-paper.37386/...

The effect of IL-2 stimulation and treatment of TRPM3 on channel co-localisation with PIP 2 and NK cell function in myalgic encephalomyelitis/chronic fatigue syndrome patients Natalie Eaton-Fitch 1 2...

Full abstract of this new paper by Staines, Marshall-Gradisnik and folks:

...The discovery of the widely expressed Transient Receptor Potential Melastatin 3 (TRPM3) as a nociceptor channel substantially targeted by certain opioid receptors, and its implication in calcium (Ca2+)-dependent Natural Killer (NK) cell immune functions has raised the possibility that TRPM3...

Yes, but not any breakthrough, they mentioned Cause & I have heard this many many times before...I will always believe the quote by Dr. Rodney Graham Professor of Rheumatology & the Hypermobility Clinic in London, UK he said this, 95% of patients diagnosed with ME/CFS have Ehlers Danlos...

Is this the TRPM3 topic? I just read a little about it. Not sure if I understood the theory behind. Why do you think it is a breakthrough? Thanks!

Chronic Fatigue Syndrome: Naltrexone as an Alternative Treatment At low doses, naltrexone is thought to disrupt the inflammatory process and restore the impaired cation channel functioning associated with chronic fatigue. Inside the latest data. Authors: Danielle Weitzer, DO Date: 18th June...

My main thought is that trpm3 is probably somewhat downstream of the main cause of me/cfs

I have not. Have never been to an endocrinologist and pregnenolone has been low on the list of every doctor I've been to however I've also taken pregnenolone with no benefit and with side effects so I'm fairly unsure on whether its beneficial for me at all