Search results for query: methylation

  1. S

    B12 causing restlessness, anhedonia and sexual dysfunction

    Sorry, i do not understand, what is causing my issues? Is it lack of co-factors? Or is the actual B12 changing things in my brain? What is methylation? Does it cause permanent damage?
  2. S

    B12 causing restlessness, anhedonia and sexual dysfunction

    I am taking 1000 mcg cyanocobalamin orally. Can I Ask How it can cause problems? Can i also Ask what it means to start methylation too quickly? Sorry if i sound like a nervous wreck, but i read B12 can cause permanent epigenetic changes due to methylation, and i am scared of permanent symptoms...
  3. caledonia

    B12 causing restlessness, anhedonia and sexual dysfunction

    Dr. Ben Lynch has done a lot of work on methylation, including B12. This Facebook post has a lot of good info on troubleshooting B12 issues. He's saying #1 to take electrolytes...
  4. helen1

    B12 causing restlessness, anhedonia and sexual dysfunction

    ...used in supplements, cyanocobalamin, is the one that can cause problems like you describe. Another possibility is that you’re starting methylation quickly and so depleting potassium especially. That seems less likely though as it doesn’t sound like you’re taking b12 cofactors, right? And...
  5. W

    B12 causing restlessness, anhedonia and sexual dysfunction

    ...Maybe they try it and do feel a reduction in the symptom. However, that doesn't prove that it has anything to do with that gene or methylation; it could be affecting one of B12's many other functions. I recently came across mention of B12 being a catalyst for propionate metabolism, which in...
  6. Sophiedw

    Lithium Orotate & Overmethylation?

    Mk4 made me worse but mk7 seems to have been the ticket. My methylation is working again now and symptoms much less severe. Thanks so much how great is this forum. Lifesaving.
  7. S

    B12 causing restlessness, anhedonia and sexual dysfunction

    ...Does it cause depletion of dopamine somehow? I Feel like there is no dopamine in my body. How does it affect the brain? I dont know if methylation is the cause or what. Seems like some extreme dopamine deficiency almost. My GP wants me to take 1000 mcg injections because my deficinecy is so...
  8. S

    Why are B12 supplements making my symptoms so much worse?

    Hi! Me again! I just wondered How B12 affects the brain. Does it cause depletion of dopamine? I get bad anhedonia and insomnia and restlessness when i take it. How does it affect neurotransmitters? Or is there another mechanism for this?
  9. I

    Methylation startup causing Abnormal Bleeding?

    Just posting to see if anyone can explain what I think is a link between Methylation and triggering prolonged and heavy menstrual bleeding...or is it just a coincidence? Not sure how much info to divulge...I have been researching Methylation since about 2017...experimenting with methylated...
  10. Pyrrhus

    Ron Davis Update

    ...reactive nature of BH4, it might be particularly susceptible to oxidative stress, and one might therefore expect to find pockets of BH4 depletion in any inflamed tissue...
  11. caledonia

    My very bad and strange experience with B12 cyanocobalamin

    ...B vitamins, not just B12. It also had some additional herbal ingredients. Possibilities: 1) You took B12 and Folic Acid. You cranked up methylation and have excess methyl groups causing issues. These type of symptoms can last for months. 2) Excess B6 can cause neurological issues like...
  12. jason30

    Folinic acid results in extreme drowsiness and brainfog

    Thank you for thinking along, this is great information. I will look further into it. Very interesting as I do have SIBO. Thanks again.
  13. jason30

    Folinic acid results in extreme drowsiness and brainfog

    Apologies, I wasn't clearly. I have 2 heterozygous (yellow) mutations on MTHFR. MTHFR C677T: +/- heterozygous mutation MTHFR A1298C: +/- heterozygous mutation And COMT met/met (+/+). So I am in the same situation as you, MTHFR wants methyl but COMT doesn't. But I have no choice...
  14. Pyrrhus

    Folates and B12 at same time

    ...it, then you can take both together. Folate and vitamin B12 work together. For more information, see: What is your understanding of the methylation cycle trap or blockage? https://forums.phoenixrising.me/threads/what-is-your-understanding-of-the-methylation-cycle-trap-or-blockage.83459/ I...
  15. Judee

    Folinic acid results in extreme drowsiness and brainfog

    I'm not totally well versed with the whole methylation line of treatment but I have seen other threads (actually lots of them) where people were not doing well on it. https://forums.phoenixrising.me/threads/hydroxy-b12-causing-sedation.76924/#post-2216361 There was a doctor on this thread who...
  16. xebex

    Folinic acid results in extreme drowsiness and brainfog

    ...bvits. However in my experience (I am COMT met/met and heterozygous for mthfr c677) I found no combination that was helpful because my MTHFR wanted methyl but my COMT doesn’t. I abandoned all methylation protocol’s as it just seems far to risky to me with way too many side effects and set...
  17. CSMLSM

    Amisulpride — A Multipurpose Drug for ME/CFS

    ...extention science and NAD+ this SIRT1 is the target. It triggers lipid metabolism more and stabilisation mechanisms for the epigenetic methylation on the DNA. This means it can make you technically younger through this epigentic stabilisation/repair. It triggers longevity and stability...
  18. Judee

    MTHFR mutation, low folate, detox issues

    ...pursued it. I do remember a doctor on YouTube saying that if SIBO is an issue it's better to resolve that first. He said bacteria use methylation too and supplementing first will just fertilize the bad guys. Who knows? Maybe that's what I was doing. I know that really doesn't answer your...
  19. D

    B vitamins and cancer

    My own conclusions is that all depend on your methylation status, since b vitamins and consequentially methylation, increase cellular activities...if your methylation status is under or normal is ok but if you overmethylates fo years could be a problem even for cancer risk. The problem is that...
  20. Hip

    Five ways to reduce your ME/CFS "wired but tired" hyperaroused brain state

    ...in my thread here. I find my sound sensitivity is dopamine connected. If you are feeling overstimulated, this can be due to overmethylation, especially if you are taking supplements which boost methylation. An effective treatment for this overmethylation overstimulation is 500 to 1000 mg of...
  21. GlassCannonLife

    Ron Davis Update

    I think Joshua Leisk's new protocol is attempting that re beta glucans
  22. B

    Ron Davis Update

    Looking into this there is a paper showing you can inhibit this pathway using Beta Glucans. Lots of overlap with other topics like Methylation, B12 and other common pathways ME/CFS patients seem to have common issues with. Paper 2 on its uses
  23. CSMLSM

    Why are B12 supplements making my symptoms so much worse?

    OK your experience but maybe not this person and a DOCTOR prescribed it and we were asked about B12. Just because someone thinks they are B12 deficient and needs B12 does not mean they think it cures everything. Me having actually had severe B12 deficiency that caused all the major symptoms and...
  24. jason30

    Coffee helps with methylation trap / blockage / issues?

    Hi all, I am a bad detoxifier since I have methylation issues. Last week I started with b12 injections due a b12 deficiency. The last 7 years I get huge reactions after exposure of toxins or pesticides, or everything which is processed by the methylation pad. So there is the biggest problem...
  25. G

    Dandruff Issue plaguing my life.

    Hey Everyone. I have been lurking on this forum lately because there is some great knowledge regarding methylation and skin issues. I figured it was time for me to post here, I have tried seeking help on my skin issue on Reddit. Raypeat forum and more. I have this problem where my scalp...
  26. caledonia

    Why are B12 supplements making my symptoms so much worse?

    I've already posted links to my methylation documents twice. Please read them. I'm not sure if I have the chemical sensitivity info in there or not. The thing to try for that is a baking soda solution. Follow the antacid recipe on the box. It's something like 1/2 tsp in 4oz of water.
  27. JES

    Why are B12 supplements making my symptoms so much worse?

    ...and my experience is B12 has not provided particularly useful to ME/CFS patients. We have this whole section on this forum dedicated to methylation treatments and over the years very few persons I am aware of recovered this route. I spent several months wasting my time on this treatment...
  28. S

    Why are B12 supplements making my symptoms so much worse?

    ...worse? As well as the restlessness? What should I do of the B12 is worsening my withdrawal-symptoms? Is it something to do with methylation or dopamine? I dont want to get permanent damage by the B12 deficiency either, so I don know what to do. I dont want to risk my cognition and...
  29. E

    Why are B12 supplements making my symptoms so much worse?

    ...thiamine/vitamin B1 deficiency. See here for more info. If you look around the forum, you would be able to find reports from several members who found that supplementing with thiamine helped with problems that arose after B12 supplementation/methylation treatment. See, for examples, here and...
  30. caledonia

    Why are B12 supplements making my symptoms so much worse?

    Yes, B12 and some of the other B vitamins can make you feel overly revved up/anxious. If what you've inadvertently done is crank up methylation, you can get relief within a few minutes with the correct supplement(s). If you're having something more like a chemical sensitivity reaction, there...