Search results for query: methylation

  1. Pyrrhus

    Help with methyl folate

    ...put forth and part of the confusion is due to the fact that people can have very different reactions. I try to approach the topic from an evidence-based perspective in this thread: https://forums.phoenixrising.me/threads/what-is-your-understanding-of-the-methylation-cycle-trap-or-blockage.83459/
  2. Dr.Lynne

    Help with methyl folate

    I've noticed a lot of stuff written on this forum about methylation, B2 and B12, and every time I try to make sense of it all, I can't seem to grasp the big picture - in part to all the minor details offered and in part to my brain fog. @Pyrrhus, you're so good at explaining things (like with...
  3. J

    THE STAGES OF METHYLATION AND HEALING

    ...way). I’m glad it’s here. It’ll probably take me a month to read and digest. I guess I’m pretty uneducated in it, but I definitely know that I have methylation issues. Could this thread include some answers for me? I really hope so….!!! You all seem like very kind people. Thank you for being...
  4. Methyl90

    THE STAGES OF METHYLATION AND HEALING

    Ok so it makes sense with B12 deficiency as it is related to Copper deficiency. As I wrote above why does copper deficiency occur only AFTER starting methylation? if it is accompanied by vitamin B12 deficiency it should follow the same line. Correct? @Crux
  5. SWAlexander

    Reporting improvement.

    ...energy and keep inflammation at bay. Can you take ibuprofen with MTHFR? Avoid medications that can deplete folate or interfere with methylation when possible: birth control pills, anticonvulsants, antacids, antidepressants, Ibuprofen, aspirin, Metformin, cholesterol-lowering medications like...
  6. xinamatusx

    High glycine? Amin acid analysis help

    Hello, I recently had an amino acid analysis done in order to get a better idea of how my methylation cycle might be doing. the three abnormal amino acids were - glycine 342 (122-322) -tyrosine 34 (38-96) -lysine 118 (119-233) I know glycine is especially important for methylation. Why...
  7. S

    Avoiding diagnostic errors in psychosomatic medicine: a case series study (Koyama et al., 2018)

    ...that prove they do? Because if not, it's extremely hypocritical for a doctor to fob a patient off when they present ideas around mold or methylation or CCI, or whatever, on the basis that there is insufficient evidence for these things to cause illness, only to be given a diagnosis for which...
  8. K

    Reporting improvement.

    I have a mutation at MTHFR, too. SWA, from where do you have the good information about the MTHFR? I found in the article by Dr. Jill Carnahan the information that I assume, if that does not function we have to deal with too much histamine MTHFR Health Tips - Jill Carnahan
  9. SWAlexander

    Reporting improvement.

    ...energy and keep inflammation at bay. Can you take ibuprofen with MTHFR? Avoid medications that can deplete folate or interfere with methylation when possible: birth control pills, anticonvulsants, antacids, antidepressants, Ibuprofen, aspirin, Metformin, cholesterol-lowering medications like...
  10. S

    What to do/take if sensitive to B12?

    ...by B12 but I no longer take it. Anything that has ever made me feel better has been an antioxidant, including B12. I went down the methylation route, but I didn't get much benefit beyond B12. I feel it's the antioxidant properties, rather than the methylation cycle, which makes B12 beneficial...
  11. M

    What to do/take if sensitive to B12?

    I know this post is over a year old, but I thought I'd comment anyway. I haven't read through all of the other comments you've made on this site, so if I say something you already know, I apologize. First, right off: you can take niacin to mitigate the caffeine-like effects of supplemental...
  12. A

    Neurochemical abnormalities in CFS: a pilot magnetic resonance spectroscopy study at 7 Tesla (Godlewska et al., 2021)

    No effect except making falling asleep easier. This has persisted despite discontinuation of it. No idea how that could happen. My B12 levels were low but after supplementation for a long time was very high, so i am off it, dropping about 1 point a day, in another 2-3 years i will be below 500...
  13. H

    Neurochemical abnormalities in CFS: a pilot magnetic resonance spectroscopy study at 7 Tesla (Godlewska et al., 2021)

    Thanks, as far as i remember you never sent me that protocol though (i might remember wrong). What dosages do you recommend for those supplements?
  14. Pyrrhus

    Neurochemical abnormalities in CFS: a pilot magnetic resonance spectroscopy study at 7 Tesla (Godlewska et al., 2021)

    A somewhat timely question. Many people, including Dikoma Shungu, have raised the possibility of using relatively simple nutritional interventions to calm the oxidative stress and related metabolic dysfunction in the brain. Anthony Komaroff and others raise the idea in their recent publication...
  15. Martin aka paused||M.E.

    Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

    Interesting... I would love to see a study looking at DNA regulation due to excessive exercise as stress (DNA methylation)..
  16. godlovesatrier

    NICOTINAMIDE MONONUCLEOTIDE - NMN

    As for the glutathione @hapl808 I take liposamal glutathione with selenium as selenium selinite (supposedly the only form that works for methylation). Remains to be seen how much it's helping me. But it's certainly allowing me to sleep.
  17. Learner1

    NICOTINAMIDE MONONUCLEOTIDE - NMN

    NMN, NR and NAD+ are all forms of niacin. Niacin is typically used to reverse methylation if one takes too many methylating nutrients. I need a lot of folate and B12, etc. but have not noticed the 137 to 187mg of NMN affecting me negatively - I need the energy boost. If I did find a problem, I...
  18. bertiedog

    NICOTINAMIDE MONONUCLEOTIDE - NMN

    ...this I have found the following - "J E Williams, OMD thinks lower doses of NMN are best, 30-50 mg because it could interfere with methylation in a negative way which could cause an increase in HISTAMINE, SEROTONIN AND OTHER AMINES" which for me equals severe, non stop migraines. This...
  19. Shanti1

    Dr Kharrazian chronic fatigue and pain syndromes course

    ...spinal issues, just TBI. He did go over B12/folate as part of a general fatigue work-up, not specific to ME/CFS. He didn't go into methylation defects or B4. I agree that most people would want to add things in one at a time and see how they react. For me personally, I have tried everything...