Search results for query: methylation

  1. M

    Hydroxocobalamin has eradicated my OCD

    ...an undermethylator. I found this paper useful https://www.americanherbalistsguild.com/sites/default/files/Proceedings/light_phyllis-_the_methylation_cycle_and_mental_health.pdf ...... "Hydroxocobalamin is the ‘protector’ form of vitamin B12. It helps to metabolize hydrogen sulfide and...
  2. L

    Hydroxocobalamin has eradicated my OCD

    ...is 1036. They are around £10. I'm not sure if I have a sulfur intolerance, how would I know if I did? I'm not as well versed at all this methylation stuff as you guys haha! I'm not sure if the b12 healing the ocd was typically down to NO tbh, I've got an autoimmune issue which would...
  3. drmullin30

    Need to Understand Lithium Dumping

    ...need to take. Here's some of what I said to @Kadar at the time: I have had a complex relationship with copper because before I started methylation and thyroid (iodine) protocols I was very copper toxic and was taking huge doses of zinc and molybdenum to bring it down. Once I got methylation...
  4. L

    Hydroxocobalamin has eradicated my OCD

    ...fatigue though. Just brainfog and really bad ocd. Interesting about the NO theory. Could it be possible its helped this but also my methylation? Something was off because I couldnt tolerate methy b12 at all it made my ocd much much worse. Anything with folic acid makes my compulsions worse...
  5. J

    Excess acetylcholine & methylation

    Found this post on reddit, this could explain a lot: "It seems like excessive methylation results in the formation of Lyso-Phosphatidylcholine (Lyso-PC), a dopaminergic neurotoxin, similar to MPTP/MPP+. It displaces D1 and D2 dopamine receptors from the cell membrane, while simultaneously...
  6. M

    Hydroxocobalamin has eradicated my OCD

    I am happy you were able to find a solution! as I ruminate a lot, I will need to try it too. I only used the methyl form in the past. Did you ever test your serum b12? What were the levels if you don't mind me asking?
  7. L

    Hydroxocobalamin has eradicated my OCD

    ...ocd goes away. If ocd thoughts come back I take more b12 and it goes. It looks likely that my deficiency in b12 has done something to my methylation but I'm not sure what. And taking the b12 has helped fixed most of my problem. So my questions are: -why is methylation and OCD being a link...
  8. R

    From zero to hero thread

    ...feel better on my feet and walking around house.. At the moment I don't know what is good or bad for me, I really don't get all of the methylation stuff.. I'm. Doing it all right yet feeling 10x worse, it makes no sense! Observations. Seems to feel tired/worse with Selenium Q10...
  9. ChookityPop

    Dante Labs are offering €199/$229 whole genome testing again up to 29th

    Do you get all those reports with the 30X WGS?
  10. C

    Need to Understand Lithium Dumping

    ...to gel a bit now. If I am understanding it correctly, what could be going on with me is that my MTHFR C677T SNP, and compromised methylation status, have created high homocysteine (which I have had for many years) which is causing a back-up in the COMT action that would normally convert SAH...
  11. drmullin30

    Need to Understand Lithium Dumping

    As Roberts mentions in there somewhere the important driver for good COMT function is the SAMe to SAH ratio so if your methylation isn't working properly you'll have a poor ratio and this is what he means by acquired dysfunction.
  12. C

    Need to Understand Lithium Dumping

    .... She noticed that certain SNPs are associated with excess lithium excretion. They are MTR+, SHMT+, and MTHFR C677T +. An out of balance methylation cycle will also cause increased lithium excretion. --Dr Amy suggests only low dose lithium support because lithium also inhibits ribonucleotide...
  13. R

    P5P and the after effects

    ...some Methyfolate and give that a go again to see if I can get the balance right and ride it out. From the initial boost I can see that b Vits should helpe but the downstream effect I do not understand and have no idea how to balance. I heard that sam-e is good for rebalancinh over...
  14. drmullin30

    Two Forms of B12 at Once = No Absorption?

    ...anything about COMT causing neuropathy. I have this SNP too and methylcobalamin has caused me to have anxiety and adrenaline problems if methylation isn't functioning well all the way around the cycle. I have my methylation functioning fairly well now and this keeps my SAMe to SAH...
  15. K

    Two Forms of B12 at Once = No Absorption?

    thank you. Given this, what forms of b12 and how much should I take? Should I switch to Methylcoblamin again?
  16. drmullin30

    Two Forms of B12 at Once = No Absorption?

    ...synthesize glutathione. Sometimes, but not usually the glycine or even less likely glutamine can be a limiting factor. Finally, if your methylation cycle isn't functioning correctly glutathione won't work correctly either. Also, I know @Pyrrhus doesn't agree, but some people have found that...
  17. K

    Two Forms of B12 at Once = No Absorption?

    I am suspecting I need to try methylcoblamin again given your comment on the hydroxy. I am COMT++ and when I stopped the methylfolate the neuropathy went away. For a while, when using hydroxy/Folinic in the AM and Adensoyl in the PM my MMA went down to 420 but using the combo of all three in one...
  18. drmullin30

    Two Forms of B12 at Once = No Absorption?

    ...have caused your problem. Without knowing that, my guess is that it was the use of hydroxocobalamin or folinic acid that killed your methylation or caused paradoxical folate and b12 deficiency and caused your MMA to rise. Your high folate and b12 numbers are very strong indicators of...
  19. Hipsman

    Dante Labs are offering €199/$229 whole genome testing again up to 29th

    ...Report - Hemiplegic Migraine Report - Hereditary Cancer Report - Leigh Syndrome Report - Marfan Syndrome Report - Metabolic Report - Methylation Mechanisms Report - Mitochondrial Diseases Report - Multiple Myeloma Report - Nephrology Report - Neurology Report - Ophthalmology Report -...
  20. Learner1

    Ribose: Why might it work for ME/CFS patients

    ...PwME. Tyrosine is used to make dopamine which is needed for motivation and completing tasks. Methionine can be used up and is needed in methylation, on the way to making glutathione. Lysine is helpful in keeping herpes viruses in check. And arginine, citrulline and ornithine are helpful in...