WPI definitely found SOMETHING. The negative testing of replication studies does not necessarily mean we will all be 'let down'. We may have to weather some storms until the full story is revealed. Very few initial discoveries like this turn out to be 100% correct. The intelligence of other labs and researchers will produce a more clear picture eventually. I know multiple labs are NOT finding XMRV in ordinary CFS samples. But I also know that there are many possibilities about why they can not find XMRV. If you do not want to be let down, then might I suggest not getting 'wrapped up' in the XMRV ideas being put forward by WPI right now. I know they want to help but they really did present their early finding as if it were a mature scientific conclusion and IT IS NOT. I have no idea why WPI is not being more cautious in their statements, perhaps there are business reasons, but regardless, after studying this issue and discussing with experts I do think WPI is on the right track, their May presentation was a bombshell probably bigger than XMRV. I don't know why nobody is picking up on that. There is no question that the mystery of CFS is starting to unravel. Please do not give up. Think of this as a year-long TV series with many up and down moments, and the final culpret not being revealed until the season-ender episode. Literally I believe we will not have a final conclusion about XMRV for a full year, until multiple replication studies have reached some consensus. I know for a fact that researchers at this time area already heading new directions because of the Science article and as a result expect there will in time be even more new discoveries. So we all need to stay tuned.