Hi all, I´m new to this board, have had chronic health problems for the last 12 + years and have been treating Lyme disease and co-infections with various antibiotic combinations for the last 3 years with not much success. Couple of weeks ago I discovered genetic testing, ordered the 23andme test and got my results back last week. I run the raw data through geneticgenie and later on livewello as well and I´m trying to interpret and understand them now but I´m feeling really overwhelmed and have a feeling that my brain fog is turning into some sort of brain snow) My main problem is terrible fatique, exhaustion, absolutely no exercise tolerance. Then flu-like symptoms, general unwell feeling, brain fog, issues with concentration, multi tasking, short term memory, understanding the info I read etc. Aches and pains of muscles, joints, bones. Swelling of small joints (hands). Stiff neck, headaches, heart problems (palpitations, arrythmia). Allergies, food intolerances, chemical sensitivities, sleep issues (staying up late, inability to fall asleep, non refreshing sleep), frequent night urination, wakig up several times during night. Issues with digestion, stomach pains, occasionally diarrhea. Persistent throat infections, bronchitis (since 2002, it all started with candida infection, then strep throat or something like that – several in a row, followed by bronchitis which became chronic as well as the throat problems. In the following years I used to take antibiotics at least once every 2 months or so.) I have been on birth control pills for 10 years (16-26), have had terrible pms since I stopped it. I also don´t tolerate alcohol very well, lately the tolerance is 0 pretty much and used to smoke for a couple of years. I have IgG3 deficiency (discovered recently, now I´m on subcuvia i.m. once monthly for that), lower lymphocytes and higher neutrophils in basic blood work, decreased T lymphocytes and increased B lymhocytes. My CD 57 is 26.6 (pretty bad). The 1st year of my Lyme treatment I took some supplements which promote methylation as well together with the antibiotics - like B12 5000mcg subligually (probably methylcobalamin), other B´s like B1, B2, B5, B6, biotin, high doses of NAC and even some reduced glutathion orally (bad absorption anyway), acetyl L-carnitine, Q10, D3, alpha-lipoic acid, quercetin, L glutamin, turmeric, vitamin E and selenium, silymarin etc. and I got slightly better but later on dropped most of the supps and declined again. I also took some of the Lyme herbs recommended by Buhner together with the antibiotic treatment. I stopped all antibiotics in the middle of September and don´t really want to go back on them now. Before my 23andMe results came back, I already started some supplements again, currently I take D3 2000 IU, lecithin 1200mg, curcumine phytosome, Ca, Mg, zinc piccolinate 50mg, EPA -DHA 2:1, buffered C 1000 twice daily, B5 500mg, selenium 200mcg, MK 7 100mcg, Gamma E complex, 1/4 of iodoral, perilla oil for allergies and quercetin with bromelain, probiotics. I also started Thorne stress B complex with 200mcg of methylfolate, 1/2 of Solgar´s 400mcg Metafolin, so I take the total of 400mcg methylfolate now, methylB12 from Jarrow, currently on 1mg daily, 1/8 of Source Naturals Dibencozide and L-Carnitine Fumarate, 855mg daily. According to the chart from Yasko, depending on my COMT and VDR status, I should probably take hydroxycobalamin instead of the methylB12, but I seem to tolerate it ok so far, had some increased brain fog when I started it (have been building up slowly from 1/4 of the tablet). I would really appreciate any help with the interpretation of my results, have been trying to research but I´m still pretty lost. Tried to upload the geneticgenie methylation results and livewello report... Thank you!