Bluebell
Senior Member
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I've recently started on mild thyroid support with NDT.
What is NDT? Dessicated something? Is it over-the-counter? Does it seem to be helping? What were your initial thyroid problems?
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I've recently started on mild thyroid support with NDT.
The CBS C699T shouldn't cause any sulfur problems at all. It's possible that the entire CBS gene can cause sulfur issues in Downs' Syndrome, where people have three copies of the chromosome, but I haven't seen any indication of 1) that CBS C699T is involved in that problem or 2) that harmful CBS upregulation can happen at all outside of Downs' Syndrome.So the +/- may not be as much of an issue? My very limited understanding of it is that it can result in issues with the sulphur pathway and excess sulfites/sulphur in the body? Is that right? When I started the methylation protocol I did a 3 week low thiols diet (really a drag) to see if I had any issues there. After adding some of the higher sulphur foods back in, I couldn't tell a difference - but have nonetheless still tried to limit my intake of them while I work on these other issues.
**While I think that people can have a good handle on biochemistry even if they don't have a professional degree in the health sciences, I'm not sure how easy it is for anyone to know quite what is going on in a particular person's body and how that would be affected by making changes (diet, supplements, daily behaviors, etc.) A lot of the advice given (even for a fee) is likely to be conjecture and repetition of received wisdom passed on by other people. This is where engaging a health professional who has extensive knowledge in the area, who has demonstrably been able to help prior clients with this, and who will monitor your progress and help you make adjustments would be good.
The good news is, we aren't living in some kind of alternate space-time dimension where you and I are the only two earthlings (whereupon I might have needed to ditch the flower persona and become a future woman).
... Come on people, keep the flirting to the emo boards!Note: I didn't mean that it sounded like a bad scenario.
... Come on people, keep the flirting to the emo boards!
Ah yes ... "friendly"I am just friendly; you know that!
there are one or two of moderators on the STTM Circadian Method/Adrenal email group who seem to know a lot about methylation and include it when helping others.
Ah yes ... "friendly"
Valentijn,The CBS C699T shouldn't cause any sulfur problems at all. It's possible that the entire CBS gene can cause sulfur issues in Downs' Syndrome, where people have three copies of the chromosome, but I haven't seen any indication of 1) that CBS C699T is involved in that problem or 2) that harmful CBS upregulation can happen at all outside of Downs' Syndrome.
The NAC was likely elevating your sulfur levels.To me it looked like my partial up-regulation of C699T causing problems, which the elimination of sulfur resolved. I imagined the supplemental MB12 letting my MTR run wild, using up all the MTHF I gave it, and having the homocysteine drawn down the CBS drain as fast as I could make it. I very much respect your opinion and insight. Help me see this another way.
Thanks, Valenijn! I have been reading the stuff of C699T and how the conclusion that it sucked everything down the drain was based on an artificial, induced, drastic truncation of the gene, not the missense mutation in question. I have a lot to learn!The NAC was likely elevating your sulfur levels.
Other external factors also may have been elevating sulfur, or other genes. But there's no research indicating that CBS C699T is capable of such a feat, and quite a bit showing that the up-regulation is beneficial.