As the title says: why would SAM-e make someone tired? This is our third try of SAM-e -- this time at the suggestion of a doctor in response to sightly high histamine and low homocysteine. Again, it has induced tiredness. No anxiety or any other signs of stimulation. Just tiredness (this is on top of the fatigue in ME/CFS of course). My question is: WHY? I'd be grateful for any suggestions. The why can be important. Background: We have been on a version of the Freddd regime since January, with far more adenosylB12 than anyone else around here and increasing doses of FMN (+mB12 and methylfolate, and other stuff etc, of course).