Lets talk NAD. It should be a miracle cure for us. Everything you read about NAD+ being able to fix mitochondria should cure us But I dont hear much success with it at least from people taking oral precursors. It just doesnt make sense. I have experimented with it and researched it alot and see an obvious conflict with CFS and NAD. Most people who have CFS have mthfr which causes low glutathione. Alot of people have had success treating their CFS by treating their mthfr and restoring glutathione. Anyone who has done this knows the dose is tricky and if you push your dose too far you can overmethylate and the cure is to take niacin which soaks up methyl units and limits methylation. But if you look at NAD, it is a nicotinamide/niacin based molecule. So if people start taking a bunch of NAD stuff, they will shut down their methylation and that would make their cfs worse. So does anyone have any solutions or workaround to be able to take nad stuff while keeping their methylation up? The first impulse seems to be to take extra methylfolate to compensate for the NAD methylation inhibition. Is it just that simple? I am going to start experimenting with this but would like to get some input. I am just wondering if this is even possible? Can you get normal methylation levels while taking large doses of nicotinamide supplements just by taking more methylation supps?