Mendus might be a useful resource for this study. We could use that platform to record and report the results.
Indeed I think Joshua would be interested in trying to set up such a study. You should certainly approach him about it.
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Mendus might be a useful resource for this study. We could use that platform to record and report the results.
Indeed I think Joshua would be interested in trying to set up such a study. You should certainly approach him about it.
I can just tell you mine, if you like.
@alex3619 and HipI was trying to find some blood lactate research on astronauts in long term space flight, when they come back to Earth, but could not find any. I don't think there is anybody who gets quite as deconditioned as such astronauts. Even their muscles atrophy. So they would set the standard for extreme deconditioning, and if ME/CFS patients did worse than long term astronauts in terms of lactate elevation, then this elevation could not be blamed on ME/CFS deconditioning.
That is interesting. I had a quick look at the source paper for the first diagram, but my science brain isn't available at the moment and I can't understand much.Also, a more easily treatable case of elevated blood lactate is thiamine deficiency:
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Thiamine deficiency lowers thiamine pyrophosphate (TPP) and thereby the conversation from pyruvate to acetyl-CoA forcing the pyruvate into lactate. Low TPP also decreases alpha-ketoglutarate dehydrogenase (α-KGDH), an important enzyme in the tricarboxylic acid (TCA) cycle:
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Thiamine treatment may also be effective in:
Fibromyalgia, Multiple Sclerosis, Parkinson's disease.
Thanks. I found that I already take more than 8 times the RDA of thiamine in my multivit, but maybe it's not very effective in that form.@MeSci
If you give thiamine a try make sure you take a Lipid-soluble thiamine like benfotiamine, sulbutiamine (passes the BBB) or allithiamine (also passes the BBB).
Did anyone buy the meter and measure their lactic acid levels?
What sort of control did you have in mind?
I am thinking that this test could include all levels of ME/CFS severity. ME/CFS patients usually have a good idea of how much exercise it takes to induce PEM, so for each patient in this lactate test, they would want to choose for themselves an exercise level which induces a degree of PEM — but obviously not a major crash.
I am also thinking that we could get a few healthy controls involved (eg, family members who do not have ME/CFS), just for comparison purposes. The healthy control could perform the same exercise as the ME/CFS patient does, so that we can have a direct comparison.
Myself, although I have a moderate level of ME/CFS, I don't actually get PEM from physical exercise, only from mental exertion. I can run a mile without too much difficulty. It's possible this might be reflected in my own lactate response.
I am in the UK.