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Which supplement has done the most for you?

Discussion in 'General ME/CFS Discussion' started by overtheedge, Aug 3, 2018.

  1. overtheedge

    overtheedge Senior Member

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    It's all in the title
     
  2. sufferingwithme

    sufferingwithme

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    Inosine. It has made me feel much better. I highly recommend it, felt much much better on it. it’s affordable, and you’ve got nothing to lose.

    I improved 1-2 points on Inosine. People have different bioavailabilitys.
     
    Last edited: Aug 4, 2018
  3. Thinktank

    Thinktank Senior Member

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    A bunch have helped me on different occasions.

    DGL - This has healed my gastritis and whenever i feel any discomfort i take 1 chewable tablet.
    Boswellia - Very anti-inflammatory, really helps with my asthma and pain in joints and muscles
    Quercetin - reduces my sinusitis to a minimum
     
  4. Moof

    Moof Senior Member

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    B12 injections and methylfolate, without a doubt. After that, sodium DCA.
     
  5. Sundancer

    Sundancer Senior Member

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    DPPIV
    theanine
    GABA
    B12
     
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  6. Wonkmonk

    Wonkmonk Senior Member

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    Lysine. The only supplement that did anything positive.
     
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  7. pamojja

    pamojja Senior Member

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    Though not for ME/CFS, with enough other conditions many supplements have done much for me (along with diet). If I had to choose only 1 it would be ascorbic acid.
     
  8. ChrisD

    ChrisD Senior Member

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    I am noticeably better in periods when I am using a decent probiotic. Otherwise High dose Vitamin C or Niacin flushes provide me with a small reset when I feel very bad and ''inflamed''.
     
  9. Wishful

    Wishful Senior Member

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    T2 or iodine (some converts to T2) is the only one that provides reliable improvement, one dose every 21 days. Cumin is an effective PEM blocker for me, but I don't know if that qualifies as a supplement. Other supplements, such as l-carnitine, apigenin and thiamine provided some benefits for a limited time, then stopped having a noticeable effect.

    Since we all seem to have a wide range of side effects from the core ME/CFS dysfunction, which supplements are effective depends on the individual.
     
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  10. Wonkmonk

    Wonkmonk Senior Member

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  11. Learner1

    Learner1 Forum Support Assistant

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    The supplements work together - one alone isn't going to do much. These have helped me the most:
    • Glutathione
    • Alpha lipoic acid
    • Custom amino acid blend
    • Phosphatidyl choline
    • B12
    • Pyridoxal-5-phosphate
    • Riboflavin-5-phosphate
    • NAD+
     
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  12. junkcrap50

    junkcrap50 Senior Member

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    *Thymosin Alpha-1
    Thymosin Beta-4
    BCP-157

    These are immune modulating peptides, but are not the oral or sublingual Russian peptides (which I don't think do anything and are easily destroyed). These are sub-q injections. I get them form a compounding pharmacy, but they are also available on many "research peptide" sites. They moved me from bedbound to doing 1-2 errands a week and even low-energy socializing. It basically removed all of my inflammation and malaise.

    *I think Thymosin Alpha-1 is the peptide that is doing most, if not all, of the immune modulation. I started all 3 at once as I was desperate. But I re-researched the peptides,and I am now thinking of taking stopping the other two, one at a time to see if I need them and to save money.
     
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  13. Judee

    Judee Senior Member

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    The only thing that does anything for me is Red Marine Algae and I can only take that on the bad days as it affects my heart a bit.

    Like lots of you, many times when I find something that works, it stops working very soon after or if I slack off and stop taking it, then the next time I try it it doesn't work. :(
     
    Last edited: Aug 4, 2018
  14. panckage

    panckage Senior Member

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    Kratom - the only thing I have found that works for long term pain management. It also gives a bit of smooth energy too
     
  15. Gondwanaland

    Gondwanaland Senior Member

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    Carcinine (glycoxil) = mTOR inhibitor, lifted fatigue completely but made me crash after 2 weeks

    P5P lifted fatigue but I crashed after 2 weeks

    B2 helped me sleep the whole night again - I have to pulse it otherwise I have no histamine in the morning to get out of bed

    Magnesium oxide restored glucuronidation and helped me tolerate a lot of foods again

    Currently I'm not tolerating any supps
     
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  16. Judee

    Judee Senior Member

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    Wow. I'm not sure I've ever heard it used to improve sleep. We have been working really hard this week to switch our hours around.

    I've tried 5-htp and on a different night L-tryptophan which knock me out but for some reason give me really bad neuro symptoms as well as a return of my IBS. (Not sure why.) :(

    :) Thanks, @Gondwanaland. I think you gave me something safer to try. Plus, my mom is histamine intolerant so we can hopefully add this to her histamine cutting regime. :thumbsup:
     
  17. Gondwanaland

    Gondwanaland Senior Member

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    Excess serotonin in the gut (from taking Tryptophan) causes IBS-D - from google search:
    Good luck!

    I use about two miligrams of B2 at bedtime. I don't want to generate an increased need for other vitamins and minerals from taking too much of one thing.
     
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  18. Judee

    Judee Senior Member

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    Awww...thank you.:D:D

    I should have researched it better online before taking it. I took the 5-htp about 2 years ago too and the L-tryptophan when I was a teen and don't remember issues but then I'm older now and this disease is more progressed especially in the last year or so.

    I'm going to stay away from them for now but will try the B2.
    Thanks for the dosage too. Our capsules say they are 100mg so we'll just open one up and take a pinch. That makes sense to not load up on a heavy dose of just the one type.
     
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  19. S-VV

    S-VV Senior Member

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    My anti bacterial metabolites drink helps:
    -A liter of orange juice
    -4g ascorbic acid
    (These two for endotoxins)
    -800mgs of Magnesium
    -Two teaspoons of malic acid
    (These two to neutralize excess D-Lactate)

    The supplement that made the biggest direct impact was MMS. It cuts right into Lyme and fungal flares.

    The one time I went into remission (but overworked, underslept and ate a horrible diet, loosing all da gainz) was after serious use uf bovine colostrum, and an E-coli probiotic.
     
  20. ruben

    ruben

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    Does anyone have any suggestions at all as to what length of time you give a supplement to work, before you abandon it?
     
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