I've finally been able to take B12 every day for the past few weeks, without too many side effects that I was having before, such as twitching when drifting off to sleep. Adding in the folic acid really helped. I currently take around 50mcg methylfolate, then an hour later usually about 125 - 250mcg of methyl B12. There have been a few times though where the reaction to the folate + B12 has been bad, after taking it for a more than 4 days in row. Such as nausea, can't concentrate, anxiety, a real "wired" feeling, body weakness. During the night I felt so nauseous and couldn't sleep properly. Kept having a weird dreams with a bit of a fever. So then when it got really bad, I'd take B3 (niacin), about 60mcg and I'd feel better an hour later. I usually need to take niacin about once a week, then I'd take a break with the B12 and folate for one day. Then I'd start the B12 + folate again, then the wiredness would get too much, then I'd have to take niacin 5 - 7 days later. Rinse and repeat. The thing is, I don't want to keep taking niacin because it could be stopping my healing and stopping the B12 and folate from doing its thing. I also want to increase my threshold to B12 and folate so then I can increase the dose, gradually, up to 1000mcg of B12 per day (+ 250mcg methylfolate), so my body and mind has a chance to actually repair itself, which I don't know if these small enough doses will do... Also, being through a bad depression this year, I want to keep on the B12 and folate so that my chemistry balance in my brain can get balanced out, and hopefully I'll be happier. So I really don't want to take niacin too often, but the reaction gets to be too much sometimes. So it's a balance between taking enough B12 + folate to tackle depression, so I don't slip into it again, and taking a little enough amount that I won't get overmethylation symptoms. Does overmethylation fade away over time? What should I do?