What is the mechanism by which paracetamol improves sleep?

[mh586]

45+ old male sleep maintenance issues for couple of years resolved by fixing the basics- blacked out room, avoiding alcohol and coffee having the biggest effect. Still even if I am able to sleep 8 hours the sleep is not as restorative as I would expect.

Recently I have noted that 500mg paracetamol (tylenol, acetaminophen ) result in truly excellent restorative sleep.

My question is: what could be the mechanism involved? What hormones are affected by paracetamol that have relevance to sleep?

I would like to modify my diet/lifestyle further to get this type of sleep without the drug.
Normal weight, fighting mild gastrointestinal and dermatological issues that indicate autoimmunity and allergies, on paleo diet since 6 years if that is in any way relevant. I have no pain the drug would help me with.

 

[Skippa]

Don't know, but, since paracetamol is an excellent antipyretic, maybe it does something to regulate temperature "down" to a perfect sleep level?

 

[mh586]

There could be somethg to it, however I did not see this effect with other antipyretics.

 

[hixxy]

Paracetamol desensitises TRPA1 calcium channels. There is some evidence that TRPA1 could play a role in some psychiatric disorders so I guess it could also play a role in some sleep disorders.

I know of an immunologist who prescribes it as part of treating mast cell disorders as well because of the role of TRPA1 in some mast cell disorders.

 

[hixxy]

Oh also the antipyretic action is also mediated by TRPA1 channels.