Couple of years ago I started trying to get my methylation cycle working properly (undermethylator). I was still learning and didn't have all the pieces, but continually working my way up I got to where I could take 40mg of Solgar Metafolin a day with negligible effect. After months of doing this with little to no effect I started adding ALCAR (fumarate doesn't really work for me) to the Metafolin, Methyl B12 and Active B12 I was taking and that last addition set me off a 5 month ride of overmethylation before fully realizing what was going on and how to reign it in with niacin. Since starting folate again 3 months ago I am having a similar issue again with a need for really high doses of Metafolin, 10mg at a time is where I start to feel some neurological brightening, but nothing spectacular. I take Jarrow Methyl B12, Source Naturals Active B12, ALCAR and TMG specifically to promote methylation, but my dose of folate is still 30-40mg a day which is far higher than I'd prefer for the response I'm getting. Oddly I am not really having any real need for additional potassium. I also recently stopped taking vitamin B1/B2 because I saw a comment from @Freddd that they may increase the need for folate. I do need a pretty sizable amount of B6 (1000mg time released + 100mg P5P a day), don't really know why I need that much but my parents and brother both need the same . When I was overmethylating, once I started I didn't really need much if any additional folate to keep the problem going for 5 months. So it's weird to still undermethylate at 30-40mg of Metafolin a day. Any idea what if anything I am missing that could be driving such a high folate need relative to the minimal response I am getting?