Alright squad, reaching out once again to try and get some insight into the medical mystery that is my life. A recap: onset of symptoms in April 2016 after several viral illnesses in a row (flu, cold, bad cold, etc.) Spent about a year with intense fatigue, joint pain, day/night reversal, tremors, memory problems, vertigo, tachycardia, etc etc. Found an LLMD in April 2017 who diagnosed me based on IgeneX IgG and IgM bands. He believed that bartonella was also at work as well as...something else that we weren't quite sure which co-infection it was. I spent a year on bicillin and azithromycin and saw very good results. All of my symptoms except the fatigue faded, and even that was much lessened. About 6 months ago I switched the antibiotics to rifampin and minocycline. Things stayed pretty much the same, with a gentle upward trend. I moved cities, insurance plans, and practitioners, and am now seeing a rheum. He tested me with the in-house Western Blot, and we saw that a few bands were no longer present! We decided to take me entirely off of the rifampin and to halve the dose of minocyline to see what would happen. At this time, he also raised some interest in my double-jointedness (before you ask, no rashes). What happened was I've started getting sicker again. Much more fatigued, joint pain flared and then settled back down, head is fuzzy with brain fog and word recall seems harder than it was a month ago. Functionality, on the whole, has definitely dropped, and my heart rate increased by 10 bpm on average. An echo revealed nothing out of the ordinary. My doc and I have to discuss what comes next for me, and I just don't know what that is. Clearly the antibiotics were doing something, but I can't stay on them for my whole life, and 18 months wasn't enough to kill the colonies completely. I haven't had any re-testing for bartonella or other coinfections. Is this still Lyme? How do I eradicate it for good? Is something else at work here, like a mast cell disorder or sjogrens (maternal grandma has it)? I don't know where to go from here, and I've always been proactive about working with my doctors as a team. If I don't give him something to go on I'm worried that he'll just waffle for long enough that my functionality continues to decrease, and I once again lose the ability to work part-time and live like a normal 22 year old.