I am homozygous for both MTRR and BHMT-08 (per my signature), so that methyl cycle has it's impediments. But low methionine came up with homocysteine in the bottom quintile, and with other indications of protein maldigestion and skeletal muscle catabolism (high 3-methyl histadine). That's just one possible explanation for low(er) homocysteine. I'm sure there are others.
I never had a test for methionine, or if I have, I need to go back and see what it was!--but I certainly have muscle catabolism. I've lost a lot of muscle mass since I've been sick. This is yet another thing I have to look into.
Thanks.
yes, my trapezium pain cleared up as soon as I came off the methylfolate, and started on Ornithine+Arginine plus charcoal at bedtime. Once I followed Ben Lynch's CBS and ACAT protocols for a few weeks, I went back to the methylfolate without any problems, so that definitely helped.
I also have a few CBS heterozygous snps, but my ACAT rs3741049 is C;C +/+, which on Promethease is labeled 'Good', so I take it, this is not the risk allele.
In the past I've had a lot of trouble taking amino acids as they completely disrupt my sleep. And the one time I took activated charcoal, it did the same. I'll have to read up on Ben Lynch's site. I do like his Seeking Health B-complex, which I do very well on. It's my go-to B-Complex with nice, low amount of those lower Bs.
I've been working on Freddd's protocol, but, having reached 3.5 mg of MeB12 and 1,200mcg of Folate, I still struggle with sleep issues and seeming folate insufficiencies or paradoxical folate insufficiency, not to mention lots of pain and muscle weakness. If I'm lucky, I get one low-pain day out of an increase in B-12, then return to the same old, same old. I've been reading a thread on ramping up folate, which for those who have done it, seems to work wonders. Getting to the sweet spot where you can do that is the challenge.
For the moment, I'm looking at lithium orotate supplements--given my TCN snps (Seeking Health has a good one)--and mulling my situation. I paused and for the second time, took only dibencozide today, about 1/2, or 5,000 mg of the sublingual and felt some mild anxiety throughout the day. We'll see how I sleep. With no folate or MeB12, the pain has been about usual.
There's so much to learn...and to figure out!:thumbdown: