Hello all, and long time since last. Sorry for being a bit lengthy here! I have the last months been working with a doctor doing functional medicine, and he has been testing me for all sorts of things. He found several issues which he believes can explain my fatigue and many of the other symptoms I am struggling with. Low gut flora diversity Low butyric acid Low IgA in the gut Low cortisol High mercury (22 nmol) Very high gut permiabillity (lactulose/mannitol test was in the upper end of red) Protozo parasites Overmethylated He believes that the mercury is the main big issue. Now with that background, I was hoping some of you could shed some light on this: Just as I was about to get started with treatment I developed some new issues that neither this doctor, nor two other doctors that I've seen can explain. All the nerves in my whole body, mostly arms and legs, would be incredibly overstimulated (for lack of better term/description), lasting for hours at a time. It was tormenting me, and it seemed that it was triggered by eating food. So I reduced eating a lot and lost some kilos. Being 193cm and about 75kg that is not the best. The whole thing actually started with muscle twitches and cramps some weeks prior to the outbreak, and after the outbreak the twitches has come and gone, and they appear all over the body, but still mostly in the legs and arms. The overstimulation of the nerves has more or less stopped, thank God, but as they have subsided more and more over the last weeks, the muscles in the legs and arms are increasingly feeling weak. Apparently they just feel weak, but are not... or the strength is there, but perhaps not the endurance... Last week at the doctor's, I had very little, or close to no, reflex in the knees when being hit with a hammer, but today it was pretty OK. But, today when he asked me to wiggle my wrists back and forth quickly the left hand was keeping a slower tempo than the right one. As I have been believing that there is a connection with eating and this my functional doctor thinks there must be a connection with leaky gut and leaky blood brain barrier. And what apparently stopped the overstimulation of the nerves was me starting on a gut healing protocol including: L-Glutamine Glycine Butyric Acid Saccharomyces Boulardii(stimulates IgA production in the gut) Lactobacillus Plantarum Probiotica Zink Selenium Broth since monday and from today, Betaine HCL But the weakness is so far progressing, and I do not like it!!!!! I am going to see a neurologist and also scheduled for MRI, but as the doctors so far are having no clue what this is - would any of you perhaps?