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We May Have Finally Discovered The Trigger That Starts Autoimmune Diseases

Discussion in 'Other Health News and Research' started by BurnA, Sep 2, 2017.

  1. BurnA

    BurnA Senior Member

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    http://www.sciencealert.com/we-may-have-found-how-runaway-train-autoimmune-diseases-get-started

     
  2. Webdog

    Webdog Senior Member

    Wasn't it Mario Capecchi at the Stanford Symposium who emphasized the importance of developing a mouse model for ME/CFS?
     
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  3. Alvin2

    Alvin2 If humans were rational...

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    Very interesting.
    What happens long term, the short term memory may be great to knock out (with Rituximab?) but if there is a long term we would need to fix it because it usually takes years to get diagnosed with ME/CFS or presumably most autoimmune diseases.

    Could this even explain why only 60% remission is achieved in Rituximab trials?
     
  4. TrixieStix

    TrixieStix Senior Member

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    Woolie, pattismith and Hutan like this.
  5. Snow Leopard

    Snow Leopard Hibernating

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    There doesn't seem to be any substantial evidence of this in humans though - each autoimmune disease seems to have it's own specific autoantibodies, rather than some generalised lack of B-Cell tolerance.
     
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  6. alex3619

    alex3619 Senior Member

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    This is the first study I have seen with this kind of specific claim. Its interesting. Its also a long way to go before we have clinical application.

    It might explain the Rituximab successes and failures. Might. So might other things. In ten or twenty years people will look back and ask why the answer is not obvious. We are mired in both a sea of uncertainty and quagmires of unfounded certainty. Or to put it another way, a lack of research and too much dogma.

    In less than two months we might have early word, however brief, on how Rituximab is doing.
     
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  7. geraldt52

    geraldt52 Senior Member

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