I was reading about people with severe 'adrenal fatigue' who can't tolerate nervous system relaxants or things that lower cortisol, due to worsened fatigue, OI, hypoglycemia etc. I'm at that point, and have to avoid seemingly benign supplements like Magnesium, or sleep aids like benzos etc. This makes it difficult to control inflammation. Certain probiotics/herbs help to an extent, but need to keep being rotated. I have had very mixed success taking time-release Vitamin C (2-3g) before bed. It helps induce sleep, but seems to induce some (subjective) low-cortisol symptoms such as nausea, decreased appetite and depression. The pay-off, when it works, is increased energy the next day, increased stress tolerance, and a reduction in crashes. However, yesterday, I ended up in a severe crash and could barely get out of bed. It scared me. I was also experiencing severe anxiety, paranoia, depression. I've wondered if it's possible that Vitamin C itself could induce a crash in those who are sensitive (and maybe those initial benefits from supplementation have developed tolerance), or if it might relate to something else; I have read Vitamin C is implicated in copper detox. I don't know how valid that theory is, but I noticed the day I felt particularly bad my stools were rust/orange-colored, which I have also read is related to copper elimination. The other thing is I have been using a different brand -- Natural Factors (which contains Bioflavonoids and Hesperidine Extract), instead of Source Naturals (which only contains Rosehip) and wasn't sure if that could relate somehow as well.